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The effects of extracts of aerial sections of Echinophora platyloba on function tests of Liver, kidney, and fat profiles of diabetic male rats induced by Streptozocin
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Ali Zarie    , Saeed Changizi-Ashtiyani , Mansour Sokhandani * , Zahra Farrokhi , Fatemeh Rassekh , Saeed Amini , Fereidoun Jahangir , Yaser Zarei Kordshouli |
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Abstract: (3754 Views) |
Background: Diabetes mellitus is a systemic metabolic disease that is specified by hyperglycemia, hyperlipidemia, hyperaminoacidemia and hyperinsulinemia. This study aimed to assesses the effects of extracts of aerial sections of Echinophora platyloba on function tests of liver, kidney, and fat profiles of diabetic male rats induced by Streptozocin.
Materials and Methods: 45 head male rat were divided into 5 diabetic control groups and 3 case diabetic groups that received alcoholic extracts of Echinophora platyloba in the doses of 75, 150, 300 mg/kg in the form of gavage. Diabetes induction was performed using intraperitoneal injection of streptozotocin with the dose of 50 mg/kg. Blood samples were taken from all groups at the end of day 21 and the rate of the factors were measured and analyzed.
Results: The rate of ALP, SGPT, HDL, LDL, cholestrol, uric acid and creatinine indicated a significant change. The rate of triglycerides and albumin indicated a decreasing and an increasing significant change than the control group, respectively. The rate of BUN and total protein indicated a decreasing and an increasing significant change than the control group, respectively. The rate of SGOT in the case group receiving the minimum extract dose (75mg/kg) indicated a decreasing significant change than the medium extract (150mg/kg).
Conclusion: The extract of Echinophora platyloba especially in the low doses causes hepatoprotective and hypolipidemic due to its antioxidant properties and increase in thyroid hormones. Moreover, some studies indicate the side effects of the extract to some organs. So, its consumption should be used in suitable doses. |
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| Keywords: Echinophora, Liver, Kidney, Diabetes, Fat profiles |
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Full-Text [PDF 374 kb]
(2233 Downloads)
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Type of Study: Applicable |
Subject:
medicine, paraclinic
Received: 2020/11/28 | Revised: 2021/09/13 | Accepted: 2021/05/1 | Published: 2021/07/3
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