History and Objectives: Due to discrepancies on the role of cholecystokinin receptors in pain and on the role of surgical processes and nerve ligation as a pain inducer and hyperalgesic agent, the present experimental study was carried.

Materials and Methods: An experimental study was performed on groups of mine mice. The unilateral nerve ligation was made on the right hind limb, according to the Seltzer’s method. The pain sensitivity was measured by the hot-plate test based on Eddy and Leimbach’s method. Antinociception was measured in a 60 min period of time (15, 30, 45, 60 min) after injection. Control group in all of the experiments were received vehicle or saline solution. Experimental group were compared with the control group.

Results: Different doses of morphine (3, 6 and 9 mg/kg) induced a dose dependent antinociception in the intact and nerve ligated animals but nerve ligation did not decrease caerulein response. In another experiment, carulein, proglumide and the combination of two drugs induced antinociception but there was no interaction between the two drugs.

Conclusion: CCK agonists or their combination with morphine can be used for the treatment of neuropathic pain. The mechanism of action of CCK agonist has not been elucidated and further research is needed to unravel its action.