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:: Volume 24, Issue 6 (Bimonthly 2020) ::
Feyz 2020, 24(6): 592-600 Back to browse issues page
Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole- induced seizures in mice
Morteza Vaghefi-Esfidani , Azhdar Heydari *
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran. , heydariazh@gmail.com
Abstract:   (2118 Views)
Background: L-carnitine, as an endogenous compound, has paradoxical effects on seizures. This study aimed to evaluate the effect of acute administration of L-carnitine alone or combination with sodium valproate on pentylenetetrazole (PTZ) induced myoclonic and tonic seizure thresholds in mice.
Materials and Methods: In this study, 64 male NMRI mice (25-30 g) were divided into 8 groups (8 animals in each group). Normal saline (as solvent), L-carnitine (50, 100, 150 and 200 mg/kg), sodium valproate (50 and 150 mg/kg) and combination of the ineffective doses of L-carnitine/sodium valproate (100.50 mg/kg) were administered by gavage. L-carnitine and sodium valproate were administrated 4 and 2 hours before seizure induction, respectively. Intravenous infusion of PTZ was used to induce seizure induction. All data were analyzed using a one-way analysis of variance (ANOVA) via SPSS version 21.0 software.
Results: The results showed that L-carnitine at doses of 150 and 200 mg/kg significantly increased the threshold of myoclonic and tonic seizures compared to the control group (P<0.01). Also, combination of the L-carnitine/sodium valproate significantly increased the threshold for tonic seizures compared to the ineffective dose of sodium valproate (P=0.007).
Conclusion: The results of this study showed that acute administration of L-carnitine increases the threshold of myoclonic and tonic seizures. Co-administration of L-carnitine with sodium valproate significantly increases the threshold for tonic seizures, also. This may be due to changes in the metabolism of sodium valproate.
Keywords: L-carnitine, Sodium valproate, Pentylenetetrazole, Seizure, Epilepsy, Mice
Full-Text [PDF 1497 kb]   (813 Downloads)    
Type of Study: Research | Subject: General
Received: 2020/08/5 | Accepted: 2020/11/24 | Published: 2021/02/8
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Vaghefi-Esfidani M, Heydari A. Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole- induced seizures in mice. Feyz 2020; 24 (6) :592-600
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Volume 24, Issue 6 (Bimonthly 2020) Back to browse issues page
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