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Investigation of the effect of vitamin D deficiency and prescribe on clinical course of bacterial pneumonia in hospitalized patients: A randomized, double-blind, placebo-controlled clinical trial
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Hasan Afzali   , Zahra Soleimani , Hosein Vasefpoor  , Roozbeh Esalatmanesh , Kamal Esalatmanesh * |
| kashan university of medical siences , esalat.kamal@yahoo.com |
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Abstract: (1570 Views) |
Background: Pneumonia is among the most important causes of mortality and disability in adults. Recently is recognized that vitamin D has a role in multiple immune pathway, has stimulant effects on immune system and facilitate anti-microbial phenomena of innate immune system. This study aimed to investigation of the effect of vitamin D deficiency and its administration on clinical course of bacterial pneumonia in hospitalized patients.
Materials and Methods: This study was performed on 120 patients with pneumonia who were randomly allocated into two groups of 60 intervention (antibiotic + vitamin D) and control (antibiotic + placebo). Vitamin D levels were measured in all patients at the beginning of admission. Changes in clinical and hemodynamic findings were assessed at baseline and 48 and 96 hours after the start of the intervention, also. The collected data were analyzed by SPSS software version 16 using one-way ANOVA, mixed analysis of variance and independent t-test.
Results: The results showed that the mean respiratory rate in the intervention group after 48 hours was significantly lower than the control group, but the mean duration of symptoms improvement was not significantly different between the two groups.
Conclusion: The results of the present study showed that vitamin D deficiency affects and exacerbates the vital and hemodynamic signs of patients with bacterial pneumonia, although vitamin D replacement therapy may correct some of these findings. However, more extensive studies with longer follow-up and higher doses of vitamin D are recommended. |
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| Keywords: Bacterial pneumonia, Vitamin D |
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Full-Text [PDF 841 kb]
(967 Downloads)
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Type of Study: Applicable |
Subject:
medicine, paraclinic
Received: 2020/06/23 | Revised: 2021/09/13 | Accepted: 2021/06/7 | Published: 2021/08/16
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