[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 25, Issue 1 (Bimonthly 2021) ::
Feyz 2021, 25(1): 761-766 Back to browse issues page
Combination effect of Methylphenidate and Risperidone in treatment of children with attention-deficit hyperactivity disorder
Fatemeh Assarian , Fatemeh Sadat Ghoreishi , Samira Ahmadian , Afshin Ahmadvand , Rezvan Saei
Department of Psychiatry, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran. , fatemehsadat.ghoreishi@gmail.com
Abstract:   (5986 Views)
Background: Attention-deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in children. Due to the high prevalence of the disorder and its psychological consequences and the lack of response to treatment in 20-30% of children to Ritalin, the present study aimed to evaluate the effect of Risperidone with Ritalin in the treatment of children with ADHD.
Material and Methods: In this clinical trial study, 60 children aged 6 to 12 years with ADHD were randomly divided into Ritalin+placebo and Ritalin+Risperidone. The dose of Ritalin was started at 0.5 mg/kg daily and increased to a maximum of 1 mg/kg. The dose of Risperidone was started at 0.25 mg daily and given up to a maximum of 1 mg daily. The severity of hyperactivity with attention deficit was assessed using the ADHD rating scale questionnaire at baseline and weeks 2, 3, 4 and 6 after drug administration. The collected data were analyzed by SPSS software version 26 using mixed ANOVA.
Results: The results showed that the two groups had a significant improvement in terms of ADHD rating scale during 6 weeks of treatment (P<0.001) but there was no significant difference between the two groups (P>0.05).
Conclusion: Risperidone and Ritalin can be effective in treating children with ADHD and are well tolerated. Also, adding Risperidone to Ritalin can prevent side effects such as insomnia and anorexia and may require a lower dose of Ritalin to control symptoms.
Keywords: Hyperactivity disorder, Attention deficit, Ritalin, Risperidone
Full-Text [PDF 753 kb]   (1227 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2020/06/23 | Revised: 2021/04/7 | Accepted: 2021/02/14 | Published: 2021/04/6
References
1. Safavi P, Hasanpour-Dehkordi A, AmirAhmadi M. Comparison of risperidone and aripiprazole in the treatment of preschool children with disruptive behavior disorder and attention deficit-hyperactivity disorder: A randomized clinical trial. JAPTR 2016; 7(2): 43.
2. Ardalan G, Farhoud D. Hyperactivity, attention and concentration deficit in preschool children .Iran J Pediatr 2002; 12(4): 53-6.
3. Association AP. Diagnostic and statistical manual of mental disorders. BMC Med 2013; 17: 133-7.
4. Briars L, Todd T. A review of pharmacological management of attention-deficit/hyperactivity disorder. J Pediatric Pharmacol Therapeutics 2016; 21(3): 192-206.
5. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biological psychiatry. J Pediatr Pharmacol Ther 2005; 57(11): 1313-23.
6. Pliszka S, Issues AWGoQ. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Can Acad Child Adolesc Psychiatry 2007; 46(7): 894-921.
7. Faker H, Davariashtiani R, Arabgol f, Rajezi S, Heydarian T, Assarian F. comparison effect of Ritalin and stimidate in the treatment of school children with attention- deficit hyperactivity disorder. Iran Neurosurgery Sci 2009; 24: 297-303.
8. Arabgol F, Panaghi L, Nikzad V. Risperidone versus methylphenidate in treatment of preschool children with attention-deficit hyperactivity disorder. Iran J Pediatr 2015; 25(1). [in Persian]
9. Aman MG, Binder C, Turgay A. Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. J Child Adolesc Psychopharmacol 2004; 14(2): 243-54.
10. Correia Filho AG, Bodanese R, Silva TL, Alvares JP, Aman M, Rohde LA. Comparison of risperidone and methylphenidate for reducing ADHD symptoms in children and adolescents with moderate mental retardation. J Am Acad Child Adolesc Psychiatry 2005; 44(8): 748-55.
11. Eapen V, Gururaj A. Risperidone treatment in 12 children with developmental disorders and attention-deficit/hyperactivity disorder. Prim Care Companion J Clin Psychiatry 2005; 7(5): 221.
12. Zargarinejad Gh, Tehranidoost R. Efficacy of parent's training on problem behaviors in ADHD children. Psychological Studies 2007; 2(3): 29-48. [in Persian]
13. Safavi P, Dehkordi AH, Ghasemi N. Comparison of the effects of methylphenidate and the combination of methylphenidate and risperidone in preschool children with attention-deficit hyperactivity disorder. J Adv Pharm Technol Res 2016; 7(4): 144.
14. Masi G, Manfredi A, Nieri G, Muratori P, Pfanner CH, Milone A. A Naturalistic Comparison of Methylphenidate and Risperidone Monotherapy in Drug-Naive Youth with Attention-Deficit/Hyperactivity Disorder Comorbid with Oppositional Defiant Disorder and Aggression. J Clin Psychopharmacol 2017; 37(5).
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Assarian F, Ghoreishi F S, Ahmadian S, Ahmadvand A, Saei R. Combination effect of Methylphenidate and Risperidone in treatment of children with attention-deficit hyperactivity disorder. Feyz 2021; 25 (1) :761-766
URL: http://feyz.kaums.ac.ir/article-1-4169-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 25, Issue 1 (Bimonthly 2021) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645