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:: Volume 24, Issue 1 (Bimonthly 2020) ::
Feyz 2020, 24(1): 56-62 Back to browse issues page
Investigate the effect of alcoholic extract of bulbs of narcissus (Narcissus tazetta L.) on indexes of renal function
Hassan Morovvati * , Nezam Armand
Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, I.R. Iran. , hmorovati@ut.ac.ir
Abstract:   (1641 Views)
Bakground: Narcissus flower has been rich in several different secondary metabolites including essential oils, trinoids, flanoids, phenolic compounds, alkaloids and has bioactive, pharmaceutical properties and is beloved in the perfume industry. This study aimed to investigate the effect of alcoholic extract of bulbs of narcissus on indexes of renal function.
Materials and Methods: In this study, 20 adult male rats were randomly divided into 3 experimental and one control group. Experimental groups received oral bulbs extract of 50, 100 and 150 mg/kg orally for 6 days. Blood samples were taken from all groups of mice on day 7 and renal function tests were performed. Data were analyzed by SPSS software version 21 and the results were presented as mean and standard deviation (Mean±SEM).
Results: Total Proteins decreased significantly (P<0.01) at 100mg/kg Narcissus bulb extract. At the dose of 150 mg/kg of extract, total protein and albumin activity significantly decreased and creatinine significantly increased (P<0.05). Urea at 150 mg/kg concentration also showed a significant increase compared to the control group (P<0.01(. BUN did not change significantly at all doses of the extract compared to the control group.
Conclusion: Significant decrease in total protein and albumin, and significant increase in urea and creatinine, indicate toxicity at high doses of Narcissus bulb extract, which needs further histological studies.
Keywords: Medicinal plant, Total protein, Bilirubin, Urea, Creatinine, Albumin
Full-Text [PDF 207 kb]   (792 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2019/11/19 | Accepted: 2020/01/18 | Published: 2020/05/16
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Morovvati H, Armand N. Investigate the effect of alcoholic extract of bulbs of narcissus (Narcissus tazetta L.) on indexes of renal function. Feyz 2020; 24 (1) :56-62
URL: http://feyz.kaums.ac.ir/article-1-4021-en.html

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