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:: Volume 24, Issue 4 (Bimonthly 2020) ::
Feyz 2020, 24(4): 404-412 Back to browse issues page
Assessment of the effect of smoking reduction on liver function tests and metabolic indices in non-alcoholic steatohepatitis smokers
Raika Jamali , Mehdi Aghamohammadi , Ommolbanin Paknejad , Shahrokh Karbalai *
Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Abstract:   (1702 Views)
Background: This study aimed to investigate the effects of smoking reduction on liver function tests and metabolic parameters in non-alcoholic steatohepatitis (NASH) smokers.
Materials and Methods: In addition to standard treatment, all patients participated in 6 sessions of “motivational interview” workshops to encourage smoking decrement. The clinical trial consisted of two successful and unsuccessful arms. Those who decreased daily cigarette smoking more than 50% were labeled as “successful” group. The “unsuccessful” group consisted of those who were decreased the daily cigarette smoking less than 50%. The successful and unsuccessful groups were 43 (41%) and 61 (59%) patients respectively. The data regarding number of daily cigarette smoking, liver function tests and metabolic parameters were checked twice, in 3 and 6 months’ time after starting the intervention.
Results: Liver function tests, metabolic parameters and liver fat content (LFC) were decreased in both arms after 6 months. The mean alanine aminotransferase, alkaline phosphatase, fasting blood sugar, insulin, cholesterol, low density lipoprotein, LFC, and waist circumference (WC) was lower in successful arm than in unsuccessful.
Conclusion: It seems that concomitant standard treatment and cigarette smoking reduction has more effect in decrement of alanine aminotransferase, serum metabolic parameters, WC and LFC in NASH smokers.

Keywords: Smoking, Liver function tests, Metabolic indexes, Non-alcoholic steatohepatitis
Full-Text [PDF 771 kb]   (1117 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2019/11/1 | Accepted: 2020/08/4 | Published: 2020/10/10
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Jamali R, Aghamohammadi M, Paknejad O, Karbalai S. Assessment of the effect of smoking reduction on liver function tests and metabolic indices in non-alcoholic steatohepatitis smokers. Feyz 2020; 24 (4) :404-412
URL: http://feyz.kaums.ac.ir/article-1-4005-en.html

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Volume 24, Issue 4 (Bimonthly 2020) Back to browse issues page
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