History and Objectives: Considering the high incidence of thyroidal nodules in mountainous and hot regions of Kashan and the importance of its rapid diagnosis and treatment and the existence of controversies in this field, this study was performed on referrals of health centers in Kashan with thyroidal nodules from 1998 to 2000.

Materials and Methods: The clinical trial strategy of this study was performed on 65 patients. At first, they were tested for FNAc and operated according to indications (Lobectomy, isthmectomy, pyramidectomy, subtotal and/or total thyroidectomy). The biopsies were evaluated pathologically and diagnostic value of FNAc was determined.

Results: Out of 65 studied cases, 55 patients were female and 10 cases were male. In addition, in 5 cases (7.7%), there existed a state of malignancy according to pathological evaluation and FNAc. Meanwhile, the sensitivity and specificity was 100% for FNAc.

Conclusion: FNAc has a high diagnostic value of thyroid nodules and it is recommended to be performed before surgical operations of the thyroid gland for all of the cases to reduce unwanted and costly operations.