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:: Volume 23, Issue 6 (Bimonthly 2019) ::
Feyz 2019, 23(6): 657-663 Back to browse issues page
The relationship between serum interleukin-10 (IL-10) and preeclampsia in pregnant women in the third trimester in Bandar Abbas
Maryam Khazaei-Koohpar , Azin Alavi
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, I.R. Iran. , alavimedic@yahoo.com
Abstract:   (2106 Views)
Background: Preeclampsia is one of the important factors in maternal and fetal mortality and it seems that changes in immunological factors such as auto antibodies and the presence of various cytokines contribute to the disease. This study aimed to determine the relationship between serum Interleukin-10 (IL-10) levels in pregnant women and preeclampsia during the third trimester of pregnancy in Bandar Abbas, southern Iran.
Materials and Methods: In this case-control study, 60 pregnant women were examined in two groups of case and control. All mothers were in the third trimester of pregnancy. Sixty pregnant women were included in the study, of which 30 women had preeclampsia (case group) and 30 women had normal blood pressure (control group). After selecting the subjects, 5cc blood samples were collected from the case group and control group. Then, the level of IL-10 was measured in the serum sample. Data were analyzed by t-student and Mann-Whitney tests.
Results:The mean IL-10 level among the mothers in the case group was 22.25 and it was 38.75 in the control group. IL-10 was significantly lower among mothers in the case group (P<0.001). The statistical analysis in this study demonstrated that if IL-10 is increased by one unit, the risk of preeclampsia decreases by 1.36 times (P=0.001).
Conclusion: Considering the results of this study, it seems that serum levels of IL-10 play a significant role in the incidence of preeclampsia among pregnant mothers. These findings can be used for diagnostic and therapeutic purposes.
Keywords: Preeclampsia, Interleukin-10, Pregnancy
Full-Text [PDF 271 kb]   (562 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/30 | Revised: 2020/02/15 | Accepted: 2019/12/21 | Published: 2020/02/12
References
1. Al-Jameil N, Aziz Khan F, Fareed Khan M, Tabassum H. A brief overview of preeclampsia. J Clin Med Res 2014; 6(1): 1-7.
2. Perez-Sepulveda A, Torres MJ, Khoury M, Illanes SE. Innate immune system and preeclampsia. Front Immunol 2014; 5: 244.
3. Kalantar F, Rajaei S, Heidari AB, Mansouri R, Rashidi N, Izad MH, et al. Serum levels of tumor necrosis factor-alpha, interleukin-15 and interleukin-10 in patients with pre-eclampsia in comparison with normotensive pregnant women. Iran J Nurs Midwifery Res 2013; 18(6): 463-6.
4. Benian A, Madazli R, Aksu F, Uzun H, Aydin S. Plasma and placental levels of interleukin-10, transforming growth factor-beta1, and epithelial-cadherin in preeclampsia. Obstet Gynecol 2002; 100(2): 327-31.
5. Szarka A, Rigo J, Jr., Lazar L, Beko G, Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol 2010; 11: 59.
6. Sykes L, MacIntyre DA, Yap XJ, Ponnampalam S, Teoh TG, Bennett PR. Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2. Mediators Inflamm 2012; 2012: 416739.
7. Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy. Front Immunol 2014; 5: 253.
8. Vural P, Degirmencioglu S, Saral NY, Demirkan A, Akgul C, Yildirim G, et al. Tumor necrosis factor alpha, interleukin-6 and interleukin-10 polymorphisms in preeclampsia. J Obstet Gynaecol Res 2010; 36(1): 64-71.
9. Daher S, Sass N, Oliveira LG, Mattar R. Cytokine genotyping in preeclampsia. Am J Reprod Immunol 2006; 55(2): 130-5.
10. Sowmya S, Ramaiah A, Sunitha T, Nallari P, Jyothy A, Venkateshwari A. Evaluation of Interleukin-10 (G-1082A) Promoter Polymorphism in Preeclampsia. J Reprod Infertil 2013; 14(2): 62-6.
11. Yang W, Zhu Z, Wang J, Ye W, Ding Y. Evaluation of association of maternal IL-10 polymorphisms with risk of preeclampsia by A meta-analysis. J Cell Mol Med 2014; 18(12): 2466-77.
12. Kalkunte S, Nevers T, Norris WE, Sharma S. Vascular IL-10: a protective role in preeclampsia. J Reprod Immunol 2011; 88(2): 165-9.
13. Cubro H, Kashyap S, Nath MC, Ackerman AW, Garovic VD. The Role of Interleukin-10 in the Pathophysiology of Preeclampsia. Curr Hypertens Rep 2018; 20(4): 36.
14. Makris A, Xu B, Yu B, Thornton C, Hennessy A. Placental deficiency of interleukin-10 (IL-10) in preeclampsia and its relationship to an IL10 promoter polymorphism. Placenta 2006; 27(4-5): 445-51.
15. Peracoli JC, Bannwart-Castro CF, Romao M, Weel IC, Ribeiro VR, Borges VT, et al. High levels of heat shock protein 70 are associated with pro-inflammatory cytokines and may differentiate early- from late-onset preeclampsia. J Reprod Immunol 2013; 100(2): 129-34.
16. Weel IC, Baergen RN, Romao-Veiga M, Borges VT, Ribeiro VR, Witkin SS, et al. Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia. PloS One 2016; 11(6): e0157584.
17. Orange S, Horvath J, Hennessy A. Preeclampsia is associated with a reduced interleukin-10 production from peripheral blood mononuclear cells. Hypertens Pregnancy 2003; 22(1): 1-8.
18. Hanna N, Hanna I, Hleb M, Wagner E, Dougherty J, Balkundi D, et al. Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts. J Immunol 2000; 164(11): 5721-8.
19. Plevyak M, Hanna N, Mayer S, Murphy S, Pinar H, Fast L, et al. Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am J Reprod Immunol 2002; 47(4): 242-50.
20. Makhseed M, Raghupathy R, El-Shazly S, Azizieh F, Al-Harmi JA, Al-Azemi MM. Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reprod Immunol 2003; 49(5): 308-18.
21. Rezaei A, Dabbagh A. T-helper (1) cytokines increase during early pregnancy in women with a history of recurrent spontaneous abortion. Med Sci Monit 2002; 8(8): CR607-10.
22. Shaper AG, Kear J, Macintosh DM, Kyobe J, Njama D. The platelet count, platelet adhesiveness and aggregation and the mechanism of fibrinolytic inhibition in pregnancy and the puerperium. J Obstet Gynaecol Br Commonw 1968; 75: 433.
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Khazaei-Koohpar M, Alavi A. The relationship between serum interleukin-10 (IL-10) and preeclampsia in pregnant women in the third trimester in Bandar Abbas. Feyz 2019; 23 (6) :657-663
URL: http://feyz.kaums.ac.ir/article-1-3885-en.html


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Volume 23, Issue 6 (Bimonthly 2019) Back to browse issues page
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