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The role of Musashi protein in spermatogenesis and male infertility
Zohreh Talebi-Yazdabadi , Kianoush Dormiani , Mahboobeh Forouzanfar , Liana Lachinani , Marzieh Tavalaee , Mohammad hossein Nasr- Esfahani *
, mh.nasr-esfahani@royaninstitute.org
Abstract:   (150 Views)
Background: Inactivation of transcription occurs during two phases of spermatogenesis. First, in spermatocytes entering the primary meiosis and the second in round and elongating spermatids. These stages of inactivated transcription demand extensive regulation of translation. Therefore, presence of the control on gene expression during spermatogenesis seems essential. In the cases that post-transcription controlling mechanisms show an abnormal function, spermatogenesis will be impaired. RNA-binding proteins has an important effect in this phenomenon. One of group of these proteins are Musashi family that play critical role during spermatogenesis and the aim of this review article is the study of the role of these protein family during spermatogenesis.
Material and Methods: This study is a review article and the selection of the papers was done using Google scholar, PubMed and Scopus databases and special key words. Then, all related English-language papers between 1994 and 2018 were considered.
Results: Several studies showed that Musashi 1 has an important role in the early stage of spermatogenesis in which spermatogonia and gonocytes proliferate, while Musashi 2 has a central role during late stage of spermatogenesis for differentiation of spermatocytes and spermatids.
Conclusion: Musashi proteins have a critical role during spermatogenesis. Severe pathological defects were detected in transgenic models with knockdown or knockout Musashi, including sperm abnormal morphology, DNA fragmentation and low fertilization potential.
Keywords: Male Infertility, Musashi, Spermatogenesis, Sperm Parameters, RNA binding proteins
     
Type of Study: Review | Subject: medicine, paraclinic
Received: 2018/12/16 | Accepted: 2019/05/7
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