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The effect of cyclooxygenase-2 inhibition on PTZ- induced seizure threshold in mice
Azam Mesdaghinia , Paria Khazaee , Azhdar Heydari *
Associate Professor , heydariazh@gmail.com
Abstract:   (72 Views)
Introduction: Previous studies have shown the protective effect of cyclooxygenase enzyme in development of convulsions, however involvement of Cyclooxygenase-2 in the pathogenesis of epilepsy has not well known. The present study was designed to explore effect of celecoxib and nimezulide (selective COX-2 inhibitors) on PTZ-induced clonic seizure threshold in mice.
Materials and methods: In this study, white male mice were randomly divided into 13 groups including intact control, vehicle (tween 80) and eleven experimental groups which received celecoxib (2.5, 5 and 10 mg/kg), nimezulide (2.5, 5 and 10 mg/kg), diazepam (0.1, 0.5 and 5 mg/kg), and combination of noneffective dose of diazepam with celecoxib and or nimezulide. PTZ-induced seizure threshold was assessed ia all groups.
Results: Nimesulide (2.5 and 5 mg/kg), celecoxib (2.5 and 5 mg/kg) and diazepam (0.5 and 5 mg/kg significantly increased of PTZ-induced seizure threshold. Also, only combination subeffective doze of diazepam (0.1 mg/kg) with celecoxib (2.5 mg/kg) significantly showed protection against PTZ-induced seizure threshold.
Conclusion: Results of the current study show the possible role of COX-2 isoenzyme in the pathophysiology of epilepsy. It is possible that some COX-2 inhibitors such as celecoxib act through GABAergic neurons and reduce excitability by increase of GABA release. Also, the difference between the effects of celecoxib and nimesolide can be attributed to the effect of these two compounds on COX-1 and COX-2 expression.
 
Keywords: seizure, cyclooxygenase-2, pentylenetetrazole
     
Type of Study: Research | Subject: General
Received: 2018/05/8 | Accepted: 2018/06/17
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Mesdaghinia A, Khazaee P, Heydari A. The effect of cyclooxygenase-2 inhibition on PTZ- induced seizure threshold in mice . Feyz. 2018; 22 (3)
URL: http://feyz.kaums.ac.ir/article-1-3599-en.html


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