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:: Volume 22, Issue 5 (Bimonthly 2018) ::
Feyz 2018, 22(5): 450-457 Back to browse issues page
The effect of regular interval training on histochemical symptoms and cytokine and neurotrophic levels of brain tissue of the Lewis rats in experimental model of multiple sclerosis
Sayed Mojtaba Hosseini , Zia Fallahmohammadi * , Vahid Talebi
Department of Exercise Physiology, University of Mazandaran, Mazandaran, I. R. Iran. , ziafalm@yahoo.com
Abstract:   (183 Views)
Background: Multiple sclerosis is an inflammatory and chronic disease of the central nervous system. Regarding the possible effects of exercise in preventing this disease, the aim of this study was to investigate the effect of 6 weeks of high intensity interval training on TNF-α, IL-10 and BDNF levels in rat brain tissue of the experimental autoimmune encephalomyelitis (EAE) model.
Materials and Methods: In this experimental study, 25 Lewis female rats, 6 weeks old, were randomly divided into 5 groups. Interval training was performed for 6 weeks and 5 days a week. An interval training program was conducted in the second week and during 6 weeks of training in each session including 10 repetitions of 1 minute. The EAE model was induced at the end of the sixth week of exercise. TNF-α, BDNF and IL-10 were measured in the brain tissue.
Results: The results of coloring showed that the amount of inflammation of the nerve tissue decreased in the interval training groups. Interval training in Lewis female rats with experimental autoimmune encephalomyelitis showed a significant decrease in TNF-α (P=0.001), but did not significantly change the IL-10 (P=0.07) and BDNF (P=0.54) levels. In addition, trained rats showed delayed clinical symptoms.
Conclusions: It seems that interval exercises with the duration and severity of the present study protocol may delay the incidence and severity of clinical symptoms and thus increase cellular protection in Lewis rats against the onset of experimental autoimmune encephalomyelitis.
Keywords: Cytokine, Experimental autoimmune encephalomyelitis, Interleukin 10, BDNF, TNF-α
Full-Text [PDF 324 kb]   (13 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/6 | Accepted: 2018/08/19 | Published: 2018/11/28
References
1. Kim TW, Sung YH. Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune ence‌ph‌alo‌myelitis mice. Neuroscience 2017; 346: 173-81.
2. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747.
3. Seamons A, Perchellet A, Goverman J. Immune tolerance to myelin proteins. Immunol Res 2003; 28(3): 201-21.
4. Reboldi A, Coisne C, Baumjohann D, Benv‌e‌n‌uto F, Bottinelli D, Lira S, et al. CC chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the init‌iation of EAE. Nat Immunol 2009; 10(5): 514-23.
5. El-behi M, Rostami A, Ciric B. Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol 2010; 5(2): 189-97.
6. Saraiva M, O'garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol 2010; 10(3): 170-81.
7. Maghsoodi N, Khosravi N, Ravasi AA. The effect of a period of selected training (aerobic and resistance) on some cytokines in male and female patients with multiple sclerosis. Sport Biosciences (harakat). 2011: 2011; 10: 5-23. [in Persian]
8. Bezheh N, Soltani M, Khaleghzade H. Effects of aerobic training in water on IL-6 and IL-10 in patients with Multiple Sclerosis. Evidence Based Care 2014; 4(2): 63-72. [in Persian]
9. Tekieh E, Zaringhalam J, Manaheji H, Magh‌soudi N, Alani B, Zardooz H. Increased serum IL-6 level time-dependently regulates hyperalgesia and spinal mu opioid receptor expression during CFA-induced arthritis. EXCLI J 2011; 10: 23.
10. Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: from bench to bedside. Phar‌m‌a‌col Ther 2005; 106(2): 163-77.
11. Bernardes D, Oliveira-Lima OC, da Silva TV, Faraco CCF, Leite HR, Juliano MA, et al. Differ‌ential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalo‌myelitis are modulated by prior and regular exercise. J Neuroimmunol 2013; 264(1-2): 24-34.
12. Caggiula M, Batocchi A, Frisullo G, Angelucci F, Patanella A, Sancricca C, et al. Neurotrophic Factors and Clinical Recovery in Relapsing Rem‌itting Multiple Sclerosis. Scand J Immunol 2005; 62(2): 176-182.
13. Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis? J Neurol Sci 2008; 265(1): 93-6.
14. Kalinowska-Lyszczarz A, Losy J. The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications. Int J Molecular Sci 2012; 13(10): 13713-25.
15. Azoulay D, Vachapova V, Shihman B, Miler A, Karni A. Lower brain-derived neurotrophic fac‌tor in serum of relapsing remitting MS: reversal by glatiramer acetate. J Neuroimmunol 2005; 167(1-2): 215-8.
16. Kierkegaard M, Lundberg IE, Olsson T, Johansson S, Ygberg S, Opava C, et al. High-intensity resistance training in multiple sclerosis—An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle stre‌ngth, walking and cognition. J Neurol Sci 2016; 362: 251-7.
17. Castellano V, White LJ. Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis. J Neurol Sci 2008; 269(1): 85-91.
18. Klaren RE, Stasula U, Steelman AJ, Hernandez J, Pence BD, Woods JA, et al. Effects of exercise in a relapsing-remitting model of experimental auto‌immune encephalomyelitis. J Neurosci Res 2016; 94(10): 907-14.
19. Turner AP, Kivlahan DR, Haselkorn JK. Exe‌rcise and quality of life among people with mul‌tiple sclerosis: looking beyond physical functioning to mental health and participation in life. Arch Physical Med Rehabil 2009; 90(3): 420-8.
20. Marquez CM, Vanaudenaerde B, Troosters T, Wenderoth N. High-intensity interval training evo‌kes larger serum BDNF levels compared with inte‌nse continuous exercise. J Appl Physiol 2015; 119 (12): 1363-73.
21. Ogura Y, Naito H, Kurosaka M, Sugiura T, Junichiro A, Katamoto S. Sprint-interval training induces heat shock protein 72 in rat skeletal mus‌cles. J Sports Sci Med 2006; 5(2): 194.
22. [22] Yaghmaei P NM, Mahdavi M,Mehrvarz T, Zahra Nazari. The effect of different doses of bee venom serum levels of interleukin-6 in Lewis rats EAE (a model for studying multiple sclerosis). Pajoohandeh J 2013; 18(2): 69-75. [in Persian]
23. Patel DI, White LJ. Effect of 10-day forced treadmill training on neurotrophic factors in experimental autoimmune encephalomyelitis. Appl Physiol Nutrition Metabol 2013; 38(2): 194-9.
24. Zhu W, Frost EE, Begum F, Vora P, Au K, Gong Y, et al. The role of dorsal root ganglia acti‌va‌tion and brain-derived neurotrophic factor in multiple sclerosis. J Cell Mol Med 2012; 16(8): 1856-65.
25. Castellano V, Patel DI, White LJ. Cytokine responses to acute and chronic exercise in multiple sclerosis. J Applied Physiol 2008;104(6):1697-702.
26. Arnett HA, Mason J, Marino M, Suzuki K, Mat‌sushima GK, Ting JP-Y. TNFα promotes proliferation of oligodendrocyte progenitors and remyelination. Nature Neuroscience 2001; 4(11): 1116-22.
27. Mancini A, Gaetani L, Di Gregorio M, Tozzi A, Ghiglieri V, Calabresi P, et al. Hippocampal ne‌uro‌‌plasticity and inflammation: relevance for mul‌tiple sclerosis. Multiple Sclerosis Demyeli‌na‌ti‌ng Disorders 2017; 2(1): 2.
28. Petereit H, Pukrop R, Fazekas F, Bamborschke S, Röpele S, Kölmel H, et al. Low interleukin-10 production is associated with higher disability and MRI lesion load in secondary progressive multiple sclerosis. J Neurological Sci 2003; 206(2): 209-14.
29. Aktunc E, Kayhan B, Arasli M, Gun BD, Barut F. The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis. Immunopharmacol Immunotoxicol 2011; 33(4): 667-75.
30. Perrella O, Sbreglia C, Perrella M, Spetrini G, Gorga F, Pezzella M, et al. Interleukin-10 and tumor necrosis factor-alpha: model of immuno‌modulation in multiple sclerosis. Neurological Res 2006; 28(2): 193-5.
31. White LJ, Castellano V, Mc Coy SC. Cytokine responses to resistance training in people with multiple sclerosis. J Sports Sci 2006; 24(8): 911-4.
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Hosseini S M, Fallahmohammadi Z, Talebi V. The effect of regular interval training on histochemical symptoms and cytokine and neurotrophic levels of brain tissue of the Lewis rats in experimental model of multiple sclerosis. Feyz. 2018; 22 (5) :450-457
URL: http://feyz.kaums.ac.ir/article-1-3597-en.html


Volume 22, Issue 5 (Bimonthly 2018) Back to browse issues page
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