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:: Volume 22, Issue 5 (Bimonthly 2018) ::
Feyz 2018, 22(5): 450-457 Back to browse issues page
The effect of regular interval training on histochemical symptoms and cytokine and neurotrophic levels of brain tissue of the Lewis rats in experimental model of multiple sclerosis
Sayed Mojtaba Hosseini , Zia Fallahmohammadi , Vahid Talebi
Department of Exercise Physiology, University of Mazandaran, Mazandaran, I. R. Iran. , ziafalm@yahoo.com
Abstract:   (3161 Views)
Background: Multiple sclerosis is an inflammatory and chronic disease of the central nervous system. Regarding the possible effects of exercise in preventing this disease, the aim of this study was to investigate the effect of 6 weeks of high intensity interval training on TNF-α, IL-10 and BDNF levels in rat brain tissue of the experimental autoimmune encephalomyelitis (EAE) model.
Materials and Methods: In this experimental study, 25 Lewis female rats, 6 weeks old, were randomly divided into 5 groups. Interval training was performed for 6 weeks and 5 days a week. An interval training program was conducted in the second week and during 6 weeks of training in each session including 10 repetitions of 1 minute. The EAE model was induced at the end of the sixth week of exercise. TNF-α, BDNF and IL-10 were measured in the brain tissue.
Results: The results of coloring showed that the amount of inflammation of the nerve tissue decreased in the interval training groups. Interval training in Lewis female rats with experimental autoimmune encephalomyelitis showed a significant decrease in TNF-α (P=0.001), but did not significantly change the IL-10 (P=0.07) and BDNF (P=0.54) levels. In addition, trained rats showed delayed clinical symptoms.
Conclusions: It seems that interval exercises with the duration and severity of the present study protocol may delay the incidence and severity of clinical symptoms and thus increase cellular protection in Lewis rats against the onset of experimental autoimmune encephalomyelitis.
Keywords: Cytokine, Experimental autoimmune encephalomyelitis, Interleukin 10, BDNF, TNF-α
Full-Text [PDF 324 kb]   (817 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/6 | Revised: 2018/11/27 | Accepted: 2018/08/19 | Published: 2018/11/28
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Hosseini S M, Fallahmohammadi Z, Talebi V. The effect of regular interval training on histochemical symptoms and cytokine and neurotrophic levels of brain tissue of the Lewis rats in experimental model of multiple sclerosis. Feyz 2018; 22 (5) :450-457
URL: http://feyz.kaums.ac.ir/article-1-3597-en.html

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Volume 22, Issue 5 (Bimonthly 2018) Back to browse issues page
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