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Regular exercises reduce the histochemical symptoms and TNF-α levels in the brain tissue of the rat rats model of experimental autoimmune encephalomyelitis (EAE) model.
Sayed mojtaba Hosseini , Zia Fallahmohammadi * , Vahid Talebi
, ziafalm@yahoo.com
Abstract:   (20 Views)
Background: Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Due to the positive effects of physical activity in the prevention of this disease, the aim of this study was to investigate the effect of 6 weeks' interval training on the levels of TNF-α, IL-10 and BDNF in the brain tissue of rat model of experimental autoimmune encephalomyelitis.
Methods: Interval training for 6 weeks and 5 days a week. Interval Training program for the second week in 6 weeks per session includes 10 repetitions was 1 minute. Work to rest ratio of 1: 2 and the total running time was 30 minutes. The disease was evaluated daily. EAE was induced at the end of the six weeks of training.
Results: The results of the staining showed that in the group treated with interval training reduced the inflammation of nervous tissue. Interval Training in female rats of race Lewis with experimental autoimmune encephalomyelitis lead to a significant reduction in TNF-α (P=0/001), but significant changes in IL-10 (P=0/07) and BDNF did not (P=0/54). In addition, rats trained clinical symptoms appeared delayed.
Conclusions: According to the duration and intensity interval training seems to be causing a delay in the onset and reduce the severity of clinical symptoms, no change in BDNF and IL-10 and TNF-α reduction in Lewis rats with experimental autoimmune encephalomyelitis.
 
Keywords: Cytokines, interval training, model EAE, multiple sclerosis
     
Type of Study: Research | Subject: General
Received: 2018/05/6 | Accepted: 2018/08/19
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