[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 22, Issue 4 (Bimonthly 2018) ::
Feyz 2018, 22(4): 362-369 Back to browse issues page
The effect of endurance and resistance exercises and consumption of hydro-alcoholic extract of nettle on the changes in weight and plasma levels of nesfatin-1 in type 1 diabetic rats
Seyed Hani Davoodi , Majid Vahidian-Rezazadeh * , Hamed Fanaei
Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, I. R. Iran. , vahidian@ped.usb.ac.ir
Abstract:   (1333 Views)
Background: Diabetes mellitus is one of the most common metabolic diseases and nettle is a plant that has been introduced as an anti-diabetes medication. Nesfatin-1 is an adipokine secreted from an adipose tissue and involved in the mechanism for glucose metabolism. This study aimed at examining the effect of an 8-week endurance and resistance training program along with the consumption of the hydro-alcoholic extract of nettle on plasma levels of nesfatin-1 in type 1 diabetic rats.
Materials and Methods: In this study, Wistar rats were divided into four groups and diabetes was induced in them by streptozotocin. The nettle extract (1mg/kg) was intraperitoneally injected daily in the "nettle", "endurance+nettle" and "resistance+nettle" groups. The "endurance+nettle" group swam in water for eight weeks, five sessions per week, and each session from 60 to 120 minutes. The "resistance+nettle" group began the exercise with 50, 75, 90, and 100 percent weight on the designed ladder, and then they gradually increased their record. Blood samples were taken directly from the hearts of the animals at the end of the 8th week.
Results: Weight loss was observed in all groups after 8 weeks. The least amount of weights in the "control", "nettle" and "resistance+nettle" groups were significantly lower than those in the beginning of the study (P<0.001). The results showed a significant increase in nesfatin-1 in the "nettle" group compared to the "control" group (P<0.01). Also, this increase was observed in the "endurance+nettle" and "resistance+nettle" groups compared to the "control" group (P<0.001).
Conclusion: Consumption of the nettle extract with exercise can increase the plasma nesfatin-1, which can be effective in controlling diabetes and preventing weight loss due to this disease.
Keywords: Aerobic exercise, Resistance exercise, Hydro-alcoholic extract of nettle, Nesfatin-1, Rat, Type 1 diabetes
Full-Text [PDF 269 kb]   (545 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/04/23 | Accepted: 2018/07/15 | Published: 2018/10/6
1. Mandrup-Poulsen T. Type 2 diabetes mellitus: a metabolic autoinflammatory disease. Dermatol Clin 2013; 31(3): 495-506.
2. Gomez-Perez FJ, Aguilar-Salinas CA, Almeda-Valdes P, Cuevas-Ramos D, Garber IL, Rull JA. HbA1c for the diagnosis of diabetes mellitus in a developing country. A position article. Arch Med Res 2010; 41(4): 302-8.
3. Khademi Z, Imani E, HeidaryKhormizi M, PoordadKhodaei A, Sarneyzadeh M, Nikparvar M. A Study on The Variation of Medicinal Plants Used for Controlling Blood Sugar and Causes of Self Medication by Patients Referred to Bandarabbas Diabetic Center. J Diabetes Nurs 2013; 1(1): 12-20. [in Persian]
4. Namazi N, Bahrami A. Effect of Hydro-alcoholic Nettle Extract on Lipid Profiles and Blood Pressure in Type 2 Diabetes Patients. Iran J Endo‌crinol Metabol 2012; 13(5): 449-58. [in Persian]
5. Fakhraee SH, Jouyandeh Z, Mehri A, Larijani B, Hasaniranjbar S. Systematic review on the effectiveness and safety of nettle herb in treating diabetes. Iran J Diabetes Lipid Disord 2013; 12(6): 507-23. [in Persian]
6. Tarighat esfanjani A, Namazi N, Bahrami A, Ehteshami M. Effect of Hydroalcoholic extract of Nettle (Urtica Dioica) on Glycemic Index and Insulin Resistance Index in Type 2 Diabetic Patients. Iran J Endocrinol Metabol 2012; 13(6): 561-8. [in Persian]
7. Lee DK, Cheng R, Nguyen T, Fan T, Kari‌yawasam AP, Liu Y, et al. Characterization of ape‌lin, the ligand for the APJ receptor. J Neurochem 2000; 74(1): 34-41.
8. Cederberg H, Laakso M. Type 2 Diabetes Mellitus and Dyslipidemia. Dyslipidemias: Humana Press, Totowa, NJ; 2015. p. 99-113.
9. Hansen BC. The metabolic syndrome X. Ann N Y Acad Sci 1999; 892(1): 1-24.
10. Oh S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443(7112): 709.
11. Gonzalez R, Perry R, Gao X, Gaidhu MP, Tsushima R, Ceddia R, et al. Nutrient responsive nes‌fatin-1 regulates energy balance and induces glucose‌-stimulated insulin secretion in rats. Endo‌crinology 2011; 152(10): 37-3628.
12. Nakata M, Manaka K, Yamamoto S, Mori M, Yada T. Nesfatin-1 enhances glucose induced insu‌lin secretion by promoting Ca2+ influx through L-type channels in mouse islet β- cells. Endocr J 2011; 58(4): 13-305.
13. Zhang AQ, Li XL, Jiang CY, Lin L, Shi RH, Chen JD, et al. Expression of nesfatin-1/NUCB2 in rodent digestive system. World J Gastroenterol 2010; 16(14): 1735-41.
14. Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone res‌ponses to two different anaerobic exercise sessions. Eur J Appl Physiol 2010; 110(4): 863-8.
15. Shimizu H, Ohsaki A, Oh S, Okada S, Mori M. A new anorexigenic protein, nesfatin-1. Peptides 2009; 30(5): 995-8.
16. Haghshenas R, Ravasi AA, Kordi MR, Hed‌ayati M, Shabkhiz F, Shariatzade Joneidi M. Effects of twelve weeks endurance training on weight, food intake, and plasma levels of nesfatin-1 in obese male rats. J Sport Biomotor Sci 2012; 5(1): 77-85. [in Persian]
17. Ghanbari-Niaki A, Hossein pour F, Fathi R, Daneshpouri M, Akhavan Niaki H, Zarkesh M, et al. Effect of 8 Weeks Endurance Training With Two Different Durations on Plasma HDL-Ghrelin in Male Rats. Iran J Endocrinol Metabol 2011 Sep 15;13(3):309-14. [in Persian]
18. Ghanbari Niaki A, Mohammadi S. Effect of 4 weeks of an aerobic (RAST) Training on hemato‌logical changes in male kick- Boxers. J Appl Exerc Physiol 2009; 5(10): 75-87. [in Persian]
19. Qujeq D, Davary S, Moazzi Z, Mahjoub S. Effect of Urtica dioica leaf extract on activities of nucleoside diphosphate kinase and acetyl co‌enzyme, a carboxylase, in normal and hyper‌glyc‌e‌mic rats. Afr J Pharm Pharmacol 2011; 5(6): 792-6.
20. Das M, Sarma B, Rokeya B, Parial R, Nahar N, Mosihuzzaman M, et al. Antihyperglycemic and antihyperlipidemic activity of Urtica dioica on type 2 diabetic model rats. J Diabetol 2011; 2(2): 1-6.
21. Delavar R, Heidarianpour A. The effect of four weeks detraining after a period of aerobic exercise training on plasma apelin levels and pain threshold in t1dm rat. J Sport Biomotor Sci 3. 2015; 7(13): 10-18. [in Persian]
22. Radák Z, Kaneko T, Tahara S, Nakamoto H, Pucsok J, Sasvári M, et al. Regular exercise imp‌roves cognitive function and decreases oxi‌dative damage in rat brain. Neurochem Int 2001; 38(1): 17-23.
23. Hornberger Jr TA, Farrar RP. Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat. Can J Appl Physiol 2004; 29(1): 16-31.
24. MacLaren D, Morton J. Biochemistry for sport and exercise metabolism: John Wiley & Sons; 2011. p. 193
25. Kadoglou NP, Vrabas IS, Kapelouzou A, Lampropoulos S, Sailer N, Kostakis A, et al. The impact of aerobic exercise training on novel adipo‌kines, apelin and ghrelin, in patients with type 2 diabetes. Med Sci Monit 2012; 18(5): CR290.
26. Kazemi F, Ebrahim K, Zahedi Asl S. Effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats. Res Med 2016; 39(4): 163-8. [in Persian]
27. Chaolu H, Asakawa A, Ushikai M, Li YX, Cheng KC, Li JB, et al. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med 2011; 2(2): 369-73.
28. Shirvani H, Ghanbari-Niaki A, Rahmati-Ahmadabad S. Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleo‌bindin-2 and ghrelin mRNA expression. IJAEP 2017; 6(1): 71-84
29. Ghanbari-Niaki A, Rahmati-Ahmadabad S, Ansari-Pirsaraei Z. Effects of aerobic training on tissue nesfatin-1/nucleobindin-2 mrna, plasma nesfatin-1 and high-density lipoprotein concen‌tration in female rats. IJHPA 2013; 4(2): 1-7.
30. Tofighi A, Mehrabani J, Khadivi SM. The effect of 8 weeks aerobic exercise on Nesfatin-1 and acylated Ghrelin in young obese men. MJMS 2014; 57(3): 562-70. [in Persian]
31. Taji Tabas A, Mogharnasi M. The effect of 10 week resistance exercise training on serum levels of Nesfatin-1 and insulin resistance index in woman with type 2 diabetes. J Diabetes Metab Disord 2016; 14(3): 179-88. [in Persian]
32. Baravati SA, Mogharnasi M, Badiakhar H, Rahimi E. Response and compatibility of plasma levels of Nesfatin-1, glucose and insulin resistance index to circuit resistance training in obese disabled men. IIOAB J 2016; 7(8): 74-81.
33. Fathi R, NazarAli P, Imeri B. The effect of 8 weeks resistance training on plasma Nesfatin-1 levels in overweight women. Exerc Metab 2014; 3(2): 105-13. [in Persian]
34. Mokhtari M, Daryanoosh F. The effect of 12 weeks resistance exercise on plasma levels of Apelin-12, Nesfatin-1 and resting heart rate in hypertensive elderly women. Med J Mashhad Univ Med Sci 2015; 58(6): 330-7. [in Persian]
35. Dadvar N, Ghalavand A, Zakerkish M, Hojat S, Alijani E, Mahmoodkhanikooshkaki R. The effect of aerobic training and Urtica Dioica on lipid profile and fasting blood glucose in middle age female with type II diabetes. Iran J Med Sci 2017; 15(6): 507-16. [in Persian]
36. Ahangarpour A, Mohammadian M, Dianat M. Antidiabetic effect of hydroalcholic Urtica dioica leaf extract in male rats with fructose-induced insulin resistance. Iran J Med Sci 2012; 37(3): 181. [in Persian]
37. Hassani Ali, Ebrahimi Maryam, Reza RM. Survey on the effect of eight weeks of regular aerobic eexercise with consumption of nettle extract on blood glucose and insulin resistance in‌dex among women with type II diabetes. J Knowledege Health 2016; 10(4): 57-64. [in Persian]
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Davoodi S H, Vahidian-Rezazadeh M, Fanaei H. The effect of endurance and resistance exercises and consumption of hydro-alcoholic extract of nettle on the changes in weight and plasma levels of nesfatin-1 in type 1 diabetic rats. Feyz. 2018; 22 (4) :362-369
URL: http://feyz.kaums.ac.ir/article-1-3586-en.html

Volume 22, Issue 4 (Bimonthly 2018) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.07 seconds with 32 queries by YEKTAWEB 4162