History and Objectives: Considering the increasing incidence of Tuberculosis and its high rate of mortality and complications, this study was carried out to evaluate the clinical and paraclinical signs and drugs complications in Loghman Hakim hospital in Tehran from 1993 to 1996.

Materials and Methods: The descriptive strategy of this study was carried out on patients with a diagnosis of Tuberculosis. In this regard, their history was taken, clinical signs were recorded and the tests Alk-Ph, SGOT, SGPT, PT, ESR, PPD, CBC, billirubin and uric acid were done until the end of study. Data for drugs side effects were analyzed using McNemar test.

Results: Out of 190 patients, 51% were male and 49% were female. Cases with an age less than 5 years had the least incidence and cases with a greater than 66 years had the highest incidence. In addition, 56.3% out of patients had pulmonary Tuberculosis. The most important clinical signs were fever (82%), cough and sputum (62.5%), nightly perspiration (20%), respiratory distress (16%) and bloody sputum (11.2%). Meanwhile, 44.2% out of them had positive smear of sputum, 32.1% had positive biopsy and for 33.6%, diagnosis was made according to clinical and X-ray findings. 90% out of the cases had normal CBC, 94% had a high CRP, 69% had a high ESR, 17% had a negative PPD and 25.8% showed an increase in SGOT and SGPT after treatment. Billirubin level also increased up to 8.4% after treatment and in 7.6% out of them there was abnormal PT after treatment.

Conclusion and Recommendations: Considering the elevated level of hepatic enzymes in patients with Tuberculosis and under treatment, especially in those with an old age, it is recommended to chose appropriate treatment according to hepatic toxicity.