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:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 239-247 Back to browse issues page
The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice
Masoumeh Asadi Motlagh , Bahareh Pakpour * , Majid Navaian
Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, I. R. Iran. , b_pakpour@yahoo.com
Abstract:   (387 Views)
Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of ethanol-induced memory.
Materials and Methods: This study was conducted on 96 NMRI mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL) was injected intra-CA1. To assess the memory, a single-trial step-down passive avoidance apparatus was used.
Results: Results showed that pre-training injection of ethanol (1mg/kg), and MCHL (0.5 ng/mouse) decreased a passive avoidance memory in the adult mice. Also, a non- effective dose of MCHL (0.005 ng/mouse) with a non- effective dose of ethanol (0.01mg/kg) induced amnesia. Also, the results showed that injection of different doses of MCHL (0.5, 0.05, and 0.005 ng/mouse) combined with an effective dose of ethanol (1mg/kg) could retrieve damaged memory by ethanol.
Conclusion: Findings of this study showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with ethanol.
Keywords: 5-HT3, Ethanol, Passive avoidance memory, Hippocapus, Mice
Full-Text [PDF 240 kb]   (111 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/02/10 | Accepted: 2018/07/4 | Published: 2018/08/4
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Asadi Motlagh M, Pakpour B, Navaian M. The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice. Feyz. 2018; 22 (3) :239-247
URL: http://feyz.kaums.ac.ir/article-1-3538-en.html

Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
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