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:: Volume 22, Issue 5 (Bimonthly 2018) ::
Feyz 2018, 22(5): 517-524 Back to browse issues page
The effect of endurance training and taxol consumption on cyclooxygenase-2 and prostaglandin E2 levels in the liver tissue of mice with cervical cancer
Maryam Firozi-Niyaki , Ali Reza Barari * , Asieh Abbassi-Daloii
Ayatollah Amoli Branch, Islamic Azad University, Amoli, I. R. Iran. , alireza54.barari@gmail.com
Abstract:   (115 Views)
Background: Herbs have a strong anti-cancer effect. Also, exercise is one of several lifestyle factors known to lower the risk of developing cancer. The aim of this study was to investigate the effect of endurance training and taxol on cyclooxygenase-2 and prostaglandin E2 in the liver tissue of mice with cervical cancer.
Materials and Methods: In this experimental study, 35 female C57 mice were randomly divided into 5 groups (n=7 in each group): control (healthy), control (cancer), complement (cancer), training-supplementary (cancer) and training (cancer). The implantation of cancerous tumors was performed under the skin of the upper pelvis. The training group completed the endurance training protocol, which included 3 sessions per week, 50 minutes per session, at a speed of 14-18 m/s for six weeks. A dose of 60 mg/kg/day of pure taxol was injected intra peritoneally. The dependent variables of this study were measured 24 hours after the last training session by ELISA.
Results: The results showed that the use of taxol and endurance training reduced the levels of cyclooxygenase-2 and prostaglandin E2 in the liver tissues of C57 mice with cervical cancer.
Conclusion: Induction of the cancerous tissue in mice with cervical cancer increases the levels of cyclooxygenase-2 and prostaglandin E2 and endurance training along with taxol may reduce these levels.
Keywords: Cervical cancer, Taxol, Endurance training, Cyclooxygenase-2, Prostaglandin E2
Full-Text [PDF 292 kb]   (12 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/02/8 | Accepted: 2018/09/11 | Published: 2018/11/28
References
1. Boyle P, Levin B. World cancer report 2008. IARC Press, International Agency for Research on Cancer; 2008.
2. Oaknin A, Rubio MJ, Redondo A, De Juan A, Cueva Bañuelos JF, Gil-Martin M, et al. SEOM guidelines for cervical cancer. Clin Transl Oncol 2015; 17(12): 1036–42.
3. Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, Saraiya M, Bray F, et al. Worldwide burden of cervical cancer in 2008. Ann Oncol 2011; 22(12): 2675-86.
4. Weaver BA. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 2014; 25(18): 2677–81.
5. Yari Khosroshahi A, Habibi Khaniani B, Naghdibadi H. Review on taxol as the most important anticancer natural drug. JMP 2006; 2(18): 1-10.
6. Dannenberg AJ, Altork NK, Boyle J, Dang C, Howe LR, weksler BB, et al. Cyclooxygense 2: a pharmacological target for the prevention of cancer. Lancet Oncol 2001; 2(9): 544-51.
7. Liu SZ, Jemiolo B, Lavin KM, Lester BE, Trappe SW, Trappe TA. Prostaglandin E2/cyclooxygenase pathway in human skeletal muscle: influence of muscle fiber type and age. J Appl Physiol 2015; 120(5): 546-51.
8. Barari AR, Mojhde MA, Farzanegi PA, Ghasemi MO. Effect of Six Weeks of Endurance Training and Aloe Vera on COX-2 and MMP-9 Levels in Mice with Breast Cancer. J Shahid Sadoughi Univ Med Sci 2016; 24(1): 65-73. [in Persian]
9. Lira FS, Yamashita A, Carnevali LC Jr, Gonçalves DC, Lima WP, Rosa JC, et al. Exercise training reduces PGE2 levels and induces recovery from steatosis in tumor-bearing rats. Horm Metab Res 2010; 42(13): 944-9.
10. Gaeini AA, Bahramian A, Javidi M . The effect of eight weeks of resistance training on stimulatory and inhibitory factors of cardiac microvascular injuries in wistar diabetic rats. JME, Vol. 3, No. 1
11. Krüger K, Bredehöft J, Mooren FC, Rummel C. Different effects of strength and endurance exercise training on COX-2 and mPGES expression in mouse brain are independent of peripheral inflammation. J Appl Physiol 2016; 121(1): 248-54.
12. Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ. Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev. 2013 Apr 30;(4) 379-86
13. Hojman P. Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans 2017; 45(4): 905-11.
14. Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain Behav Immun 2013; Suppl: S75-87.
15. Beaudry RI, Liang Y, Boyton ST, Tucker WJ, Brothers RM, Daniel KM, et al. Meta-analysis of Exercise Training on Vascular Endothelial Function in Cancer Survivors. Integr Cancer Ther 2018; 17(2): 192-9.
16. Rahmati Z, Payam Nour V, Bazdi KG, Ebrahimi P. Compare production of taxol in natural tissues of Taxus baccata L. and Taxus berevifolia Nutt. Within vitro condition. Iran J Biol 2017; 30(1): 159-72.
17. Yari Khosroushahi A, Naderi-Manesh H, Toft Simonsen H. Effect of Antioxidants and Carbohydrates in Callus Cultures of Taxus berevifolia: Evaluation of Browning, Callus Growth, Total Phenolics and Paclitaxel Production. Bioimpacts 2011; 1(1): 37-45.
18. Segal R, Zwaal C, Green E, Tomasone JR, Loblaw A, Petrella T. Exercise for people with cancer: a clinical practice guideline. Curr Oncol 2017; 24(1): 40–6.
19. Kripp M, Heußer AL, Belle S, Gerhardt A, Merx K, Hofmann WK, Hofheinz RD. Does physical activity improve quality of life in cancer patients undergoing chemotherapy? Oncol Res Treat 2015; 38(5): 230-6.
20. Hojman P, Gehl J, Christensen JF, Pedersen BK. Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. Cell Metab 2018; 27(1): 10-21.
21. Wiggins JM, Opoku-Acheampong AB, Baumfalk DR, Siemann DW, Behnke BJ. Exercise and the Tumor Microenvironment: Potential Therapeutic Implications. Exerc Sport Sci Rev 2018; 46(1): 56-64.
22. De Oliveira F, Maifrino LB, De Jesus GP, Carvalho JG, Marchon C, Ribeiro DA. The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovariectomized mice. An Acad Bras Cienc 2013; 85(3): 1157-64.
23. Larkins TL, Nowell M, Singh S, Sanford GL. Inhibition of cyclooxygenase- 2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer 2006; 6: 181-6.
24. Calder PC. N–3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters of another fishy tale? Nutr Res 2001; 21(1-2): 309-41.
25. Shao N, Lu Z, Zhang Y, Wang M, Li W, HuZ. Interlukin8 Upregulates integrin B3 Expression and Promotes estrogen receptor- negative breast cancer cell invasion by activating the Pi3k/AKt/ NF- KB Pathway. Cancer Lett 2015; 364(2): 165- 72.
26. Timothy HD, Bishop-Bailey CH, Liu HJ, Schaefers OC. Cycloox ygenase-1 and -2 isoenzymes. Int J Biochem Cell Biol 1999; 31(5): 551-7.
27. Anampa J, Makower D, Sparano JA. Sparano. Progress in adjuvant chemotherapy for breast cancer: an overview. BMC Med 2015; 13(195): 1-13.
28. Choi J, Park JG, Ali S, Choi SJ, Baek KH. Systematic Analysis of the Anticancer Agent Taxol-Producing Capacity in Colletotrichum Species and Use of the Species for Taxol Production. Mycobiology 2016; 44(2): 105–11.
29. Weaver BA. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 2014; 25(18): 2677–81.
30. Reinecke P, Knopf C, Schmitz M, Schneider EM, Gabbert HE, Gernarz CD. Growh inhibitory effects of paclitaxol on human epitheloid sarcoma in vitro: heterogeneity of response and the multidrug resistance phenotype. Cancer 2000; 88(7): 1614-22.
31. Yazdani D, Shahnazi S, Rezazadeh S, Pirali Hamadani M. Review on yew tree (Taxus spp.). JMP 2005; 3(15): 1-8.
32. Na HK, Surh YJ. peroxisome proliferator-activated receptor γ (PPAR γ) ligands as bifunctional regulators of cell proliferation. Biochem Pharmacol 2003; 66(8): 1381-91.
33. Mohammadi-Motlagh H, Mansouri K, Mostafaie A. Plants as useful agents for angiogenesis and tumor growth prevention. Physiol Pharmacol 2010; 14(3): 297-312.
34. Hooshmand Moghadam B, Kordi MR, Mahdian S. The effect of Barberry Juice supplement on Prostaglandin E2 level caused by intense aerobic activity in active young girls. J Birjand Univ Med Sci 2017; 24: 1-9. [in Persian]
35. Choobine S, Akbarnejad A, Borjian M, Kordi MR. The Effect of Omega-3 Supplementation on Serum Prostaglandin E2 in Athlete Women after a Single Bout of Exhaustive Exercise. Harakat 2013; 4(15): 121-33.
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Firozi-Niyaki M, Barari A R, Abbassi-Daloii A. The effect of endurance training and taxol consumption on cyclooxygenase-2 and prostaglandin E2 levels in the liver tissue of mice with cervical cancer. Feyz. 2018; 22 (5) :517-524
URL: http://feyz.kaums.ac.ir/article-1-3537-en.html


Volume 22, Issue 5 (Bimonthly 2018) Back to browse issues page
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