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:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 248-257 Back to browse issues page
The effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats
Seyyed Ali Hosseini * , Mozhgan Ahmadi , Anahita Sharifi , Saeideh Shadmehri , Abdossaleh Zar
Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, I. R. Iran. , alihoseini_57@yahoo.com
Abstract:   (468 Views)
Background: Diabetes is a chronic disease which can lead to increased levels of leptin and lipid profile. The aim of this study was to examine the effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats.
Materials and Methods: In this experimental study, 56 diabetic rats were divided into 7 groups of 8 rats including control, resistance training, 30 mg/kg genistein consumption, 10 mg/kg genistein consumption, resistance training and 30 mg/kg genistein consumption, resistance training and 10 mg/kg genistein consumption, and sham. The training groups performed a resistance training program for 8 weeks and 5 sessions per week.
Results: Resistance training had a significant effect on reduction of leptin, triglyceride, cholesterol and very-low-density lipoprotein (VLDL) (P≤0.05). Genistein consumption had a significant effect on reduction of leptin and increased high-density lipoprotein (HDL) levels (P≤0.05) and had no effect on reduction of triglyceride, cholesterol, LDL and very low-density lipoprotein (VLDL) (P≥0.05). Resistance training along with genistein consumption had an interactional effect on reduction of leptin, triglyceride, cholesterol, LDL, and VLDL and increased HDL (P≤0.05). Also, 10 mg/kg and 30 mg/kg genistein consumption had similar effects on reduction of leptin and increased HDL levels in diabetic rats (P≥0.05).
Conclusion: Resistance training along with genistein consumption has interactional effects on leptin and lipid reduction in streptozotocin-induced diabetic rats.
Keywords: Diabetes, Resistance training, Genistein, Leptin, Lipid profile
Full-Text [PDF 352 kb]   (107 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/12/30 | Accepted: 2018/06/18 | Published: 2018/08/4
References
1. American Diabetes Association. Classification and diagnosis of diabetes. Sec. 2. In Standards of Medical Care in Diabetesd 2016. Diabetes Care 2016; 39(Suppl.1): S1-S22. Diabetes Care 2016; 39(9):1653.
2. Olokoba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Med J 2012; 27(4): 269-73.
3. Christian A, Elena G, Jerry LN, Klaus L. Mecha‌nisms by which diabetes increases cardio‌vascular disease. Drug Discov Today Dis Mech 2007; 4(3): 131-40.
4. Rahimi N, Marandi SM, Kargarfard M. The effect of eight weeks aquatic training on lipid profile of patients who suffer from type II diabetes. J Isfahan Med Sci 2011; 29(148).
5. Akbarpour M. The effect of resistance training on serum levels of adipokine and inflammatory markers of cardiovascular disease in obese men. Qom Univ Med Sci J 2013; 7(3): 1- 0.
6. Chai SB, Sun F, Nie XL, Wang J. Leptin and coronary heart disease: A systematic review and meta-analysis. Atherosclerosis 2014; 233(1): 3-10.
7. Bandaru P, Shankar A. Association between plasma leptin levels and diabetes mellitus. Metab Syndr Relat Disord 2011; 9(1): 19-23.
8. Hosseini SA, Nikhbakht H, Azarbayjani MA. The effect of aqua extract of saffron with resistance training on glycemic indexes of streptozotocin induced diabetic rats. Armaghan Danesh J 2013; 18 (4): 284-94. [in Persian]
9. Iranmanesh S, Vahdati A, Afrouz T. Com‌pa‌ri‌son of the effects of ethinyl estradiol and genistein on serum lipids and lipoproteins of hyper‌choles‌tr‌olemic male rats. J Physiol Pharmacol 2006; 10(2): 159-64.
10. Szkudelski T, Nogowski L, Pruszyńska-Osz‌małek E, Kaczmarek P, Szkudelska K. Genistein restricts leptin secretion from rat adipocytes. J Steroid Biochem Mol Biol 2005; 96(3-4): 301-7.
11. Hashemi HS, Hosseini SA. The effect of moderate intensity endurance training and lipid lo‌w‌ering genistein in Streptozotocin induced diabetic rats. J Shahrekord Univ Med Sci 2017; 19 (1): 10- 23.
12. SosicJurjevic B, Filipovic B, Ajdzanovic V, Brkic D, Ristic N, Stojanoski MM, et al. Sub‌cutaneously administrated genistein and daidzein decrease serum cholesterol and increase triglyceride levels in male middle-aged rats. Exp Biol Med 2007; 232(9): 1222-7.
13. Schrader C, Ernst IM, Sinnecker H, Soukup ST, Kulling SE, Rimbach G. Genistein as a pot‌en‌tial inducer of the anti-atherogenic enzyme para‌oxonase-1: Studies in cultured hepatocytes in vitro and in rat liver in vivo. J Cell Mol Med 2012; 16 (10): 2331- 41.
14. Bitto A, Altavilla D, Bonaiuto A, Polito F, Minutoli L, Di Stefano V, et al. Effects of aglycone genistein in a rat experimental model of post‌meno‌pausal metabolic syndrome. J Endocrinol 2009; 200(3): 367-76.
15. Tian HS, Zhou GQ, Zhu ZY. Evaluation of cardioprotective effects of genistein against diab‌etes-induced cardiac dysfunction in rats. Trop J Pharm Res 2015; 14(11).
16. YuHan H, Melissa AL, Alicia G, Kimberly K. Endurance exercise training programs intestinal lipid metabolism in a rat model of obesity and type 2 diabetes. Physiol Rep 2015; 3(1): e12232.
17. Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids Health Dis 2017; 16(1): 132.
18. Pesta DH, Goncalves RLS, Madiraju AK, Strasser B, Sparks LM. Resistance training to imp‌rove type 2 diabetes: working toward a prescription for the future. Nutr Metab 2017; 14: 24.
19. Dotzert MS, McDonald MW, Murray MR, Nickels JZ, Noble EG, Melling CJ. Effect of combined exercise versus aerobic-only training on skeletal muscle lipid metabolism in a rodent model of type1 diabetes. Can J Diabetes 2017; S1499-2671(17): 30314- 3.
20. SosićJurjević B, Filipović B, Ajdzanović V, Brkić D, Ristić N, Stojanoski MM et al. Subcutaneously administrated genistein and daidzein decrease serum cholesterol and increase triglyceride levels in male middle-aged rats. Exp Biol Med 2007; 232(9): 1222-7.
21. Dehghan F, Hajiaghaalipour F, Yusof A, Muniandy S, Hosseini SA, Heydari S, et al. Saffron with resistance exercise improves diabetic param‌eters through the GLUT4/AMPK pathway in-vitro and in-vivo. Sci Rep 2016; 6: 25139- 42.
22. Annibalini G, Lucertini F, Deborah A, Luciana V, Annamaria G, Elena B et al. Concurrent aerobic and resistance training has anti-inflammatory effects and increases both plasma and leukocyte levels of IGF-1 in late middle- aged type 2 diabetic patients. Oxidative Med Cell Lon 2017; 2017: 1- 10.
23. Khosro E, Hovanloo F, Teimoorian M, Saadati M, Shahvali Koohshoori Y, et al. Effects of resis‌tance training combined with green tea treat‌ment on hyperglycemia and lipid profile in diabetic rats. JMP 2016; 1(57): 74- 81.
24. Ghadiri B, Abadi N, Marandi Mo, Mojtahedi Ho, Asfarjani F. Effects of aerobic exercise on serum leptin in obese and overweight. Isfahan Med Sch J 2012; 30(183): 392-400.
25. Shahidi F, Pirhadi S. The Effect of Physical Exercise and Training on Serum Leptin Levels. RJMS 2014; 21(126): 1-14.
26. Nia FR, Hojjati Z, Rahnama N, Soltani B. Leptin, heart disease and exercise. World J Sport Sci 2009; 2(1): 13-20.
27. Barzegari A, Mahdirejei HA. Effects of 8 weeks resistance training on plasma vaspin and lipid profile levels in adult men with type 2 diabetes. Caspian J Intern Med 2014; 5(2): 103- 8.
28. Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147(6): 357-69.
29. Khosro E, Hovanloo F, Teimoorian M, Saadati M, Shahvali Koohshoori Y, Fallah Huseini H. Effects of resistance training combined with green tea treatment on hyperglycemia and lipid profile in diabetic rats. JMP 2016; 1(57): 74-81.
30. Naaz A, Yellayi S, Zakroczymski MA, Bunick D, Doerge DR, Lubahn DB et al. The soy isoflavone genistein decrease adipose deposition in mice. Endocrinology 2003; 144(8): 3315-20.
31. Llaneza P, González C, Fernandez-Iñarrea J, Alonso A, Diaz F, Arnott I et al. Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women. Phyto Med 2011; 18 (4): 245- 250.
32. Behloul N, Wu G. Genistein: a promising therapeutic agent for obesity and diabetes treatment. Eur J Pharm 2013; 698 (1-3): 31-8.
33. Kim MH, Park JS, Seo MS, Jung JW, Lee YS, Kang KS. Genistein and daidzein repress adipo‌genic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis. Cell Prolif 2010; 43(6): 594- 605.
34. Bitto A, Altavilla D, Bonaiuto A, Polito F, Minutoli L, Di Stefano V, et al. Effects of aglycone genistein in a rat experimental model of post‌meno‌pausal metabolic syndrome. J Endocrinol 2009; 200(3): 367-76.
35. Tian HS, Zhou GQ, Zhu ZY. Evaluation of cardioprotective effects of genistein against diab‌etes-induced cardiac dysfunction in rats. Trop J Pharm Res 2015; 14(11): 2015- 22.
36. Scheiber MD, Liu JH, Subbiah MT, Rebar RW, Setchell KD. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 2001; 8(5): 384-92.
37. Ho SC, Chen YM, Ho SS, Woo JL. Soy isoflavone supplementation and fasting serum glu‌co‌se and lipid profile among postmenopausal Chin‌ese women: A double-blind, randomized, placebo-controlled trial. Menopause 2007; 14 (5): 905-12.
38. Iranmanesh S, Vahdati A, Afrouz T. Com‌pa‌rison of the effects of ethinyl estradiol and genistein on serum lipids and lipoproteins of hyper‌cho‌le‌strolemic male rats. J Physiol Pharmacol 2006; 10(2): 159-64.
39. Delevatti R, Marson E, Kruel LF. Effect of aquatic exercise training on lipids profile and glycemia: a systematic review. Rev Andal Med Deporte 2015; 8(4): 163-70.
40. Eatemady BA, Kargarfard M, Mojtahedi H, Rouzbehani, R, Dastbarhagh H. Comparison of the effects of 8-weeks aerobic training and resistance training on lipid profile in patients with diabetes type 2. Isfahan Univ Med Sci J 2014; 32: 524-33.
41. Saremi A. Sporting exercise and diabetes mellitus type2: a review on evidences. J Cell Tissue 2011; 2(3): 171-81.
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Hosseini S A, Ahmadi M, Sharifi A, Shadmehri S, Zar A. The effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats. Feyz. 2018; 22 (3) :248-257
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Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
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