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Histological Analysis of Experimental Babesiosis Induced Testiculopathy in Mouse
Seyed Hamid Shariati , Ali Shalizar Jalali *, Bijan Esmaeilnejad , Ramin Mazaheri-Khameneh
Assistant Professor , a.shalizar@urmia.ac.ir
Abstract:   (274 Views)
Background: The babesias are second common blood parasites in mammalian after the trypanosomes and babesiosis as an emerging zoonotic disease has caused great concern. The main goal of this study was to disclose the testicular histological alterations following experimental babesiosis induction by Babesia bigemina in mouse.
Materials and Methods: In this experimental study, 24 adult male mice were randomly categorized into four equal groups including untreated control, sham (2.0 ml normal saline intraperitoneally at the time of babesiosis induction), splenectomy and experimental babesiosis. Experimental babesiosis was induced in splenectomized mice through 2.0 ml intraperitoneal injection of infected heparinized blood sample belonging to a cow with confirmed Babesia bigemina infection. All animals were euthanized after 5 days and testicular histology was evaluated following infection confirmation through microscopic and molecular analyses.
Results: Experimental babesiosis caused significant reductions in the cross-sectional area, quality, maturation and number of seminiferous tubules as well as drastic testicular morphological alterations as evidenced by severe hypospermatogenesis and spermatogenic maturation arrest compared to control, sham and splenectomy groups.
Conclusion: These findings revealed that Babesia bigemina infection can lead to testicular damage in mice probably through microcirculatory disruption and blood flow reduction.
Keywords: Histology, Mouse, Testis, Babesia bigemina
     
Type of Study: Research | Subject: General
Received: 2017/09/16 | Accepted: 2018/01/22 | Published: 2018/01/22
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Shariati S H, Shalizar Jalali A, Esmaeilnejad B, Mazaheri-Khameneh R. Histological Analysis of Experimental Babesiosis Induced Testiculopathy in Mouse . Feyz. 2018; 22 (1)
URL: http://feyz.kaums.ac.ir/article-1-3428-en.html


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