History and Objectives: Considering the high incidence of migraine attacks and significance of a knowledge of its pathogenesis and the hypothesis of using serum prolactin level as a marker of its diagnosis, this study was carried out to find out a relationship on referrals of Kerman neuroscience center.

Materials and Methods: This study was carried out on 20 cases with a definite diagnosis of migraine and 20 cases with non-migraine headache according to HIS criterion. Blood prolactin level was measured before attacks and drug consumption and during attacks and data were statistically analyzed.

Results: Out of 40 patients, case group had a reduction in prolactin level from 5.3±3.7 to 4.4±2.4 and control group had a reduction from 5.7±2.9 to 5.4±3.4. In addition, the difference was not significant.

Conclusion and Recommendations: There was not any increase in serum prolactin during acute attacks of migraine. It is recommended to conduct more studies for evaluation of increased dopaminergic activity as a key causative factor of migraine.