[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 21, Issue 1 (Bimonthly 2017) ::
Feyz Med Sci J 2017, 21(1): 51-56 Back to browse issues page
Effect of garlic on plasma homocysteine level in ischemic heart disease patients
Mohadeseh Sadat Mousavian , Fariba Raygan * , Mohsen Taghadosi , Seyyed Alireza Moravveji , Majid Mazochi
Department of Cardiovascular, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran. , raygan_f@kaums.ac.ir
Abstract:   (4449 Views)

Background: Decreasing the high homocysteine level of serum as one of the risk factors of cardiovascular disease can reduce the occurrence and complications of myocardial infarction. Garlic is identified as one of the main decreasing factors of high homocysteine level. So this study was carried out to determine the garlic effect on high homocysteine level in ischemic heart disease (IHD) patients.

Material and Methods: This observational study was carried out on IHD patients (n=60) attended to heart clinic of Kashan (Isfahan, Iran). Two equal groups of patients (n=30) were administered with 800 mg garlic pills daily for 6 weeks (equvalent to 4gr fresh garlic) and placebo for 6 weeks, respectively. Before and after the  intervention the plasma homocysteine, high density lipoproteine (HDL), triglyceride (TG) and low density lipoproteine (LDL) levels were measured using the ELISA) technique and TG, HDL and enzymatic techniques, respectively.    

Results: The mean age of patients was 60.6±10.1 with 39 male (65%) and 21 female (35%). At the end of study the mean plasma homocysteine level was decreased from 4.6 mol/µl to 4.4 mol/µl; while in placebo group it increased from 4.5 mol/µl to 4.6 mol/µl. However, for the comparison of the effects two drugs on homocysteine, TG, HDL and LDL level, as the confounding factor, no significant difference was seen.  

Conclusion: A daily garlic use of 800 mg for 6 weeks has no effect on serum   homocysteine and lipids levels. The topic requires further research in future.

Keywords: Garlic, Homocysteine, Serum lipids, Ischemic heart disease
Full-Text [PDF 216 kb]   (1265 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/02/28 | Revised: 2017/07/19 | Accepted: 2017/02/28 | Published: 2017/02/28
References
1. Fauci S, Kasper L, Longo L, Braunwald E, Hauser L, LrryJamson J. Principlees of Harrison s Internal Medicine. 17th ed. Mcgraw-hill; 2008.
2. Naqvi M. Statics of deaths in 23 provinces of the country in 1380. Tandis; 1382.
3. Prasad K. Homocysteine, a risk factor for cardiovascular disease. Int J Angiol 1999; 8(1): 76-86.
4. Ceperkovic Z. The role of increased levels of homocysteine in the development of cardiovascular diseases. Med Pregl 2006; 59(3-4): 143-7.
5. Weiss N, Papatheodorou L, Morihara N, Hilge R,Ide N. Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. J Ethnopharmacol 2013; 145(1): 162-7.
6. Zylberstein DE, Bengtsson C, Björkelund C, Landaas S, Sundh V, Thelle D, et al. Serum homocysteine in relation to mortality and morbidity from coronary heart disease. American heart association. Circulation 2004; 109(5):601-6.
7. Stampfer MJ, Malinow MR. Can Lowering Homocysteine Levels Reduce Cardiovascular Risk?. New England J Med 1995; 332(5): 328-9.
8. Reis RP, Azinheira J, Reis HP, Bordalo e Sa A, Tavares J, Adao M, et al. prognosis significance of blood homocysteine after myocardial infarction. Rev Port Cardiol 2000; 19(5): 581-5.
9. Weiss N, Keller C, Hoffmann U, Loscalzo J. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc Med 2002; 7(3): 227-39.
10. Dorland W. Dorland's Pocket Medical Dictionary. Elsevier Saunders; 2012.
11. Weiss N, Ide N, Abahji T, Nill L, Keller Ch, Hoffmann U. Aged garlic extract improves Homocysteine-induced endothelial dysfunction in macro- and microcirculation. J Nutr 2006; 136(3): 750S-4S.
12. NaserAhmadia B, Nabavia V, Hajsadeghia F, Zeba I, Floresa F, Ebrahimib R, et al. Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis. Int J Cardiol 2013; 168(3): 2310-4.
13. Yeh YY, Yeh SM. Homocysteine-lowering action is another potential cardiovascular protective factor of aged of aged garlic extract. J Nutr 2006; 136 (3 Suppl): 745S-6S.
14. Yeh YY, Lim HS, Yeh SM, Picciano MF. Garlic extract attenuates hyperhomocysteinemia caused by folic acid deficiency in the rat. Nutr Res 2004; 25(1): 93-102.
15. Kemper J. Garlic (allium sativum).
16. Available at: www.Mcp.edu/Hrbal/Dfault 2000.
17. Morihara N1, Ide N, Weiss N. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. J Ethnopharmacol 2011; 134(3): 711-6
18. Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorder. Nutr J 2002; 1(1): 1.
19. Davis LE, Shen J, Royer RE, In vitro Synergism of concentrated Allium sativum Extract and Amphotericin B against Cryptococcus neoformans. Planta Med 1994; 60(6): 546.
20. Rahman K, Lowe GM. Garlic cardiovascular disease: a critical review. J Nutr 2006; 136(3Suppl): 736S-40S.
21. Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. Effect of allicin from garlic powder on serum lipid and blood pressure in rat fed with a high cholesterol diet. Prostaglandins Leukot Essent Fatty Acid 2000; 62(4): 253-9.
22. Ali M, Thomson M. Consumption of a garlic clove aday could be beneficial in preventing thrombosis. Prostaglandins Leukot Essent Fatty Acid 1995; 53(3): 211-2.
23. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce level of serum lipid?. Am J Med 1993; 94(6): 632-5.
24. Ashraf R, Aamir K, Shaikh AR, Ahmed T. Effect of garlic on dislipidemia in patients with type2 diabets mellitus. J Ayub Med Coll Abbottabad 2005; 17(3): 60-4.
25. Ebadi SA, Rahimi Lenji E, Taghadosi M, Khorshidi A, Akbari H. Effect of garlic on blood sugar in patients with type 2 diabetes mellitus. Feyz 2007; 11 (1): 20-5. [in Persian]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mousavian M S, Raygan F, Taghadosi M, Moravveji S A, Mazochi M. Effect of garlic on plasma homocysteine level in ischemic heart disease patients. Feyz Med Sci J 2017; 21 (1) :51-56
URL: http://feyz.kaums.ac.ir/article-1-3283-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 21, Issue 1 (Bimonthly 2017) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4660