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Comparison of efficacy and tolerability of tretinoin gel 0.05% with adapalene gel 0.1% in mild to moderate acne vulgaris
Akram Ansar , Pedram Alirezaei , Sajjad Daneshyar *, Bita Sharafi , Saadat Torabian
, s.danshyar72@yahoo.com
Abstract:   (383 Views)

Background: Acne vulgaris is a inflammatory skin disease.Topical retinoids with significant anti-inflammatory properties are used for treatment of acne.The common side effect of topical retinoid is local irritation.The aim of this study was evaluate the efficacy and tolerability of tretinoin and adapalene in patients with mild to moderate acne vulgaris.

Materials and Methods: In this randomized double blind clinical trial, 50 patients presenting to dermatology clinic of Farshchian hospital with mild to moderate facial acne were recruited. Patients were divided into two groups.the first group received tretinoin gel 0.05% and second group apalene gel 0.1%. The severity of acne (measured by Global Acne Grading System (GAGS)) and tolerability was evaluated in beginning of the trial, and 4 and 12 weeks thereafter in both groups.

Results: The mean GAGS score in beginning of the study was 49.56 (SD=12.24) in adapalene and 47.76 (SD=11.34) in tretinoin group (p=0.592). This score dropped to 35.00 (SD = 11.13) in adapalene and 25.28 (SD = 8.17) in tretinoin group in week 4 (p = 0.001). A further GAGS score decline was observed in week 12 (25.08+9.00 in adapalene and 12.12+4.71 in tretinoin group (p< 0.001)). Concerning tolerance, there was no significant difference between two groups at the end of weeks 4 and 12 (p =1.00 and p = 0.747 respectively).

Conclusions: Adapalene 0.1% and tretinoin 0.05% are both effective and safe in treatment of mild to moderate acne vulgaris, although tretinoin gel showed more efficacy in reducing GAGS score.­Both treatments were equally tolerated.

Keywords: Acne vulgaris, tretinoin, adapalene
     
Type of Study: Research | Subject: medicine, paraclinic
Received: 2017/01/8 | Accepted: 2017/11/11 | Published: 2018/01/10
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Ansar A, Alirezaei P, Daneshyar S, Sharafi B, Torabian S. Comparison of efficacy and tolerability of tretinoin gel 0.05% with adapalene gel 0.1% in mild to moderate acne vulgaris . Feyz. 2018; 22 (1)
URL: http://feyz.kaums.ac.ir/article-1-3236-en.html


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