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:: Volume 20, Issue 6 (Bimonthly 2017) ::
Feyz 2017, 20(6): 509-517 Back to browse issues page
Effect of cyclic intravenous Iloprost therapy in patients with Idiopathic Pulmonary Artery Hypertension
Majid MalekMohammad, Babak Sharif-Kashani *, Fatemeh Monjazebi, Katayon Khosravi
Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran. , babaksharifkashani@yahoo.com
Abstract:   (2462 Views)

Background: Prostacyclin have positive effects in improving the cardiopulmonary variables, signs and the hemodynamics of cases with a  idiopathic pulmonary artery hypertension (IPAH).The objective of this study was to determine the benefits of intermittent intravenous Iloprost infusion on IPAH cases.

Material and Methods: This longitudinal study was conducted on IPAH cases (no=20) at Massih Daneshvari Hospital (2011-2013), treated with cyclic intravenous Iloprost. The   treatment consisted of a 6 hours/day Iloprost infusion for three consecutive days. Every 6 weeks the infusion was repeated again with a velocity of 0.5-2.0 ng/kg/min. Before, during and after the completion of functional class, six-minute walk test (6MWD), pulmonary artery pressure (PAP), right ventricular pressure (RVP), and plasma NT-ProBNP level were measured.

Result: At follow-up, NYHA score, PAP, RVP, NT-ProBNP and PASP were significantly decreased (P<0.001), while the distance walked in 6MWD was significantly increased.

Conclusion: Our results suggest that cyclic intravenous Iloprost might improve the NYHA score, PAP, RVP and can provide a protection against the development or worsening of PAH in patients with IPAH.

Keywords: Iloprost, Idiopathic Pulmonary Artery Hypertension
Full-Text [PDF 261 kb]   (560 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/01/1 | Accepted: 2017/01/1 | Published: 2017/01/1
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MalekMohammad M, Sharif-Kashani B, Monjazebi F, Khosravi K. Effect of cyclic intravenous Iloprost therapy in patients with Idiopathic Pulmonary Artery Hypertension. Feyz. 2017; 20 (6) :509-517
URL: http://feyz.kaums.ac.ir/article-1-3224-en.html


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