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:: Volume 21, Issue 5 (Bimonthly 2017) ::
Feyz 2017, 21(5): 422-432 Back to browse issues page
The effect of lovastatin on cognition impairment induced by bilateral electrical lesion of nucleus basalis magnocellularis in the Alzheimer’s disease model in adult male rats
Azade Eskandary , Ahmad Ali Moazedi , Hossein Najaph Zade Varzi , Firoz Ghadery Pakdel , Mohammad Reza Akhond
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran. , azade.eskandary@gmail.com
Abstract:   (3505 Views)
Background: Statins, inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, are widely used as medication to lower cholesterol levels in human patients. Much evidence indicates that statins can also exert neuroprotective actions. So, this study aimed at examining the effect of lovastatin on cognition deficit induced by bilateral electrical lesion of nucleus basalis magnocellularis (NBM) in the Alzheimer’s disease model in adult male rats.
Materials and Methods: In this experimental study, 56 adult male wistar rats were divided into 8 groups (n=7): control (intact), NBM lesion group (which received electrically- induced lesion 0.5 mA in 3s), sham group (the electrode was impaled into the NBM with no lesion(, lovastatin groups (lesion+1, 5, 10, 20 mg/kg) and DMSO 5% group (NBM lesion +DMSO 5%). Acquisition and retention testing was done by using an eight-radial arm maze in which the patterns of arm entries were recorded for calculating working memory errors, reference memory error and latency in each group.
Results: The bilateral NBM lesion resulted in significant reduction of spatial memory in acquisition and retention tests in the form of increased working and reference memory errors compared to the control group (P<0.05). Post-lesion treatment with lovastatin improved the parameters of spatial memory errors in the acquisition and retention tasks compared to the lesion group.
Conclusion: The electrical NBM lesion can reduce spatial memory function and the lovastatin therapy after brain injury improved cognitive disorders. It seems that lovastatin by reducing the activity of the acetylcholinesterase enzyme and increasing acetylcholine transferase enzyme activity can cause improvement in learning and memory capability.
Keywords: Alzheimer’s disease, Nucleus basalis magnocellularis, Cognitive performance, Radial maze, Lovastatin
Full-Text [PDF 337 kb]   (1123 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/12/4 | Revised: 2017/12/10 | Accepted: 2017/09/25 | Published: 2017/11/14
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Eskandary A, Moazedi A A, Najaph Zade Varzi H, Ghadery Pakdel F, Akhond M R. The effect of lovastatin on cognition impairment induced by bilateral electrical lesion of nucleus basalis magnocellularis in the Alzheimer’s disease model in adult male rats. Feyz 2017; 21 (5) :422-432
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Volume 21, Issue 5 (Bimonthly 2017) Back to browse issues page
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