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:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 267-273 Back to browse issues page
The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats
Saied Kamal Sadat-Hoseini , Valiollah Dabidi Roshan *
Department of Exercise Physiology, Faculty of Physical Education, University of Mazandaran, Babolsar, I. R. Iran. , vdabidiroshan@yahoo.com
Abstract:   (677 Views)
Background: In the last decade, cancer incidence increases progressively with age and older patients cannot participate in treatment programs due to the special physical condition and side effects of anti-tumor drugs. Therefore, the aim of this study was to examine the effect of six-week voluntary wheel running exercise on doxorubicin (DOX)-induced hepatotoxicity in aging model rats.
Materials and Methods: Thirty-two Wistar male rats were randomly assigned to exercise and control groups with 4 subgroups. All subjects received a daily injection of D-galactose for nine weeks (100 mg/kg/day, intraperitoneally). The training protocol included six weeks of voluntary wheel running exercise. Doxorubicin was administrated intraperitoneally (1mg/kg/day) for 15 days. Superoxide dismutase (SOD) and apoptosis-inducing factor (AIF) levels were measured after liver tissue homogenization by enzyme-linked immunosorbent assay (ELISA) method.
Results: Administration of cumulative dose of DOX caused no significant decrease in SOD and AIF levels (P=0.797, and P=0.869, respectively). Six weeks of voluntary wheel running exercise led to insignificant decrease in SOD and insignificant increase in AIF in comparison to the  control group (P=0.377, and P=0.948, respectively).
Conclusion: According to the results of the present study, the six-week voluntary wheel running exercise has no significant effect on DOX-induced hepatotoxicity in aging model rats.
Keywords: Voluntary exercise, Doxorubicin, Hepatic toxicity, Oxidative stress, Apoptosis
Full-Text [PDF 254 kb]   (209 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/31 | Accepted: 2018/06/17 | Published: 2018/08/4
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Sadat-Hoseini S K, Dabidi Roshan V. The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats. Feyz. 2018; 22 (3) :267-273
URL: http://feyz.kaums.ac.ir/article-1-3153-en.html

Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
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