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:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 267-273 Back to browse issues page
The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats
Saied Kamal Sadat-Hoseini , Valiollah Dabidi Roshan *
Professor Department of Exercise Physiology, Faculty of Physical Education, University of Mazandaran, Babolsar, I. R. Iran. , vdabidiroshan@yahoo.com
Abstract:   (234 Views)
Background: In the last decade, cancer incidence increases progressively with age and older patients cannot participate in treatment programs due to the special physical condition and side effects of anti-tumor drugs. Therefore, the aim of this study was to examine the effect of six-week voluntary wheel running exercise on doxorubicin (DOX)-induced hepatotoxicity in aging model rats.
Materials and Methods: Thirty-two Wistar male rats were randomly assigned to exercise and control groups with 4 subgroups. All subjects received a daily injection of D-galactose for nine weeks (100 mg/kg/day, intraperitoneally). The training protocol included six weeks of voluntary wheel running exercise. Doxorubicin was administrated intraperitoneally (1mg/kg/day) for 15 days. Superoxide dismutase (SOD) and apoptosis-inducing factor (AIF) levels were measured after liver tissue homogenization by enzyme-linked immunosorbent assay (ELISA) method.
Results: Administration of cumulative dose of DOX caused no significant decrease in SOD and AIF levels (P=0.797, and P=0.869, respectively). Six weeks of voluntary wheel running exercise led to insignificant decrease in SOD and insignificant increase in AIF in comparison to the  control group (P=0.377, and P=0.948, respectively).
Conclusion: According to the results of the present study, the six-week voluntary wheel running exercise has no significant effect on DOX-induced hepatotoxicity in aging model rats.
Keywords: Voluntary exercise, Doxorubicin, Hepatic toxicity, Oxidative stress, Apoptosis
Full-Text [PDF 254 kb]   (20 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/31 | Accepted: 2018/06/17 | Published: 2018/08/4
1. Marques-Aleixo I, Santos-Alves E, Mariani D, Rizo-Roca D, Padrão AI, Rocha-Rodrigues S, et al. Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitocho‌ndrial toxicity and oxidative stress. Mitochondrion 2015; 20: 22-33.
2. Sadat-Hoseini SK, Dabidi Roshan V, Shojaei Shahrokhababdi M. Effects of time courses of treadmill training in tissue toxicity induced by Different doses of doxorubicin in multiple organs. RJMS 2017; 23 (151): 31-42. [in Persian]
3. Sakr S.A, Mahran H. A, Lamfon H.A. Protective effect of ginger (Zingiber officinale) on Adriamycin - induced hepatotoxicity in albino rats. J Med Plant Res 2011; 5(1): 133-40.
4. Zolfagharzadeh F, Dabidi Roshan VD. Pre‌treat‌ment Hepatoprotective Effect of Regular Aerobic Training against Hepatic Toxicity Induced by Doxorubicin in Rats. Asian Pacifi J Cancer Prev 2013; 14(5): 2931-6.
5. Katsuhito N, Shuhei F, Ayano O, Hiroki K. Protective effects of taurine on doxorubicin-induced acute hepatotoxicity through suppression of oxi‌dative stress and apoptotic responses. Anti-Cancer Drugs 2016; 27(1): 17-23.
6. Alishahi A, Dabidi-Roshan V, Hedayati M. Pretreatment Effects of Regular Aerobic Training on the IGF System and Hepatotoxicity Induced by Doxorubicin in Rats. Asian Pac J Cancer Prev 2013; 14 (12): 7427-31.
7. Jamali N, Dabidi Roshan V, Sadat-Hoseini SK. Hepatic damage and oxidative Stress induced by acute administration various dosages of Doxo‌rubicin: Pretreatment Effect of six weeks regular aerobic exercise. Urmia Med J 2016; 27(4): 310-20. [in Persian]
8. Sadat-Hoseini SK, Dabidi Roshan V. The Interactive Effects of two forced and voluntary exercise training method and Nanocurcumin sup‌plement on Doxorubicin-induced Hepatotoxicity in aging induced by D-galactose. Tehran Univ Med J 2017; 24 (11):807-816. [In Persian]
9. Waltke LJ. An Overview of Cancer Rehabi‌litation and Exercise in the Literature: Promoting Increased Referrals to Improve Oncology Out‌comes. J Patient Cent Res Rev 2014; 1(3): 137-141.
10. Campisi J. Aging, Cellular Senescence, and Cancer. Annu Rev Physiol 2013; 75: 685-705.
11. Fu C, Wang T, Wang Y, Chen X, Jiao J, Ma F, et al. Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose. J Pharm Biomed Ana‌l 2011; 55(5): 1067-74.
12. Lee J, Cho JY, Kim WK. Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis. Nutr‌ition Res Pract 2014; 8(3): 284-91.
13. Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Exp‌ Biol Med 2012; 237(12): 1483–92.
14. Ashrafi J, Dabidi-Roshan V, Zolfagharzadeh F. Tissue toxicity Induced by Doxorubicin in rats: protective role of aerobic regular exercise. Urmia Med J 2014: 25(4): 353-62. [in Persian]
15. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol 2009; 64(4): 811-27.
16. Moreira AC, Branco AF, Sampaio SF, Cunha-Oliveira T, Martins TR, Holy J, et al. Mitochondrial apoptosis-inducing factor is involved in doxo‌rubicin-induced toxicity on H9c2 cardiomyoblasts. Biochim Biophys Acta 2014; 1842(12): 2468-78.
17. Siu P, Bodyak N, Bae S, Rigor D, Kang P.M. Doxorubicin induces caspase-independent apop‌tosis in transgenic mice overexpressing CrmA. Circulation 2006; 114: II532.
18. Ascensão A, Magalhães J, Soares JM, Ferreira R, Neuparth MJ, Marques F, et al. Moderate endu-rance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the devel¬opment of cardiac apoptosis. Am J Physiol Heart Circ Physiol 2005; 289(2): 722-31.
19. Courtney SM, Kim JH, Macias BR, Canon CN, Lawler JM. The effects of exercise on caspase-independent mitochondrial proteins in regards to age-related apoptosis. Int J Exerc Sci 2009; 2(1): 37.
20. Lien CY, Jensen BT, Hydock DS, Hayward R. Short-term exercise training attenuates acute doxo-rubicin cardiotoxicity. J Physiol Biochem 2015; 71(4): 669-78.
21. Marques-Aleixo I, Santos-Alves E, Balça MM, Moreira PI, Oliveira PJ, Magalhães J, et al. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cell-ular quality control signaling. Mitochondrion 2016; 26: 43-57.
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Sadat-Hoseini S K, Dabidi Roshan V. The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats. Feyz. 2018; 22 (3) :267-273
URL: http://feyz.kaums.ac.ir/article-1-3153-en.html

Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
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