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:: Volume 20, Issue 3 (Bimonthly 2016) ::
Feyz 2016, 20(3): 196-204 Back to browse issues page
Effect of hydro-alcholic extract of Pelargonium graveolens L. on serum lipid profile in male rat
Fatemeh Heydari, Naser Mirazi *
Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, I. R. Iran. , mirazi205@gmail.com
Abstract:   (3549 Views)

Background: Hyperlipidemia is considered as the major modifiable risk factor in the process of cardiovascular disorders. Pelargonium graveolens has several medicinal properties. The aim of this study was to investigate the effects of hydro-alcholic extract of Pelargonium graveolens (EPG) on serum lipid profile in male rat.

Materials and Methods: In this experimental study, male Wistar rats (n=35, weight 180-200 gr) were divided in five equal groups: Control (normal diet); Sham1 and 2 [high-fat diet(HFD) and HFDL (HFD + Lovastatin  20 mg/kg)]; Treatment groups 1 and 2 [HFD + EPG (150mg/kg and 300mg/kg), respectively] for 28 days. At the end of experiments, blood samples were collected directly from heart for serum lipid evaluation. All data were expressed as Mean±SE at a statistical significance difference level of P<0.05.

Results: The data of this study showed that when compared to Sham  group the consumption  of EPG in animals   fed by HFD, the serum levels of cholesterol, TG and  LDL were decreased, while HDL was increased significantly (P<0.001).

Conclusion: The use of EPG can play an important role in decreasing serum cholesterol level and other serum lipids compared to Lovastatin. This finding may be attributed to the presence of antioxidants in EPG and their cholesterol synthesis inhibition mechanisms.

Keywords: Pelargonium, Lovastatin, Rat, Cholesterol
Full-Text [PDF 313 kb]   (1197 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/08/8 | Accepted: 2016/08/8 | Published: 2016/08/8
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Heydari F, Mirazi N. Effect of hydro-alcholic extract of Pelargonium graveolens L. on serum lipid profile in male rat. Feyz. 2016; 20 (3) :196-204
URL: http://feyz.kaums.ac.ir/article-1-3076-en.html

Volume 20, Issue 3 (Bimonthly 2016) Back to browse issues page
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