[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 2 (Bimonthly 2016) ::
Feyz 2016, 20(2): 141-146 Back to browse issues page
Comparative effect of single bout of continuous endurance and high intensity interval exercise on serum BDNF in rat
Marzieh Skandari, Gholam Hosein Nazemzadegan *, Farhad Daryanosh, Mehdi Samadi, Shirin Honarpisheh, Mahmoud Hasanpor
Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, Shiraz University, Shiraz, I. R. Iran. , nazemzad@shirazu.ac.ir
Abstract:   (1524 Views)

Background: Continuous endurance exercise positively affects the brain via increasing brain-derived neurotrophic factor (BDNF). Therefore, in this study, comparative effect of single bout of continuous endurance exercise (CEE) and high intensity interval exercise (HIIE) on serum BDNF in rat was investigated.

Materials and Methods: In this experimental study rats (n=30) have randomly divided into three (CEE, HIIE and Control) groups. Following habituation to treadmill all groups (Except for Control) performed the single bout exercise of the target group. At the end of the exercise blood samples were taken. Data were analyzed using ANOVA.

Results: The results showed that BDNF level in the CEE group was significantly higher than HIIE (P<0.001) and Control group (P<0.001), while no difference between the Control and HIIE groups.

Conclusion: It seems that CEE is considered as an appropriate intervention in increasing BDNF and this factor is more affected by the duration than the intensity of exercise. Therefore, for achieving benefits of exercise on the central nervous system, performing prolonged activities are probably more useful.

Keywords: BDNF, Continuous endurance exercise, High intensity interval exercise
Full-Text [PDF 251 kb]   (901 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/06/18 | Accepted: 2016/06/18 | Published: 2016/06/18
References
1. Voss MW, Vivar C, Kramer AF, van Praag H. Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn Sci 2013; 17(10): 525-44.
2. Huang T, Larsen KT, Ried‐Larsen M, Møller NC, Andersen LB. The effects of physical activity and exercise on brain‐derived neurotrophic factor in healthy humans: A review. Scand J Med Sci Sports 2014; 24(1): 1-0.
3. Barde YA, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J 1982; 1(5): 549.
4. Dugich‐Djordjevic MM, Peterson C, Isono F, Ohsawa F, Widmer HR, Denton TL, et al. Immunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain. Eur J Nucl Med 1995; 7(9): 1831-9.
5. Kawamoto Y, Nakamura S, Nakano S, Oka N, Akiguchi I, Kimura J. Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain. Neuroscience 1996; 74(4): 1209-26.
6. Binder DK, Scharfman HE. Mini review. Growth Factors 2004; 22(3): 123-31.
7. Ebadi M, Bashir RM, Heidrick ML, Hamada FM, Refaey HE, Hamed A, et al. Neurotrophins and their receptors in nerve injury and repair. Neurochem Int 1997; 30(4-5): 347-74.
8. Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller LD. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 2002; 9(5): 224-37.
9. Soppet D, Escandon E, Maragos J, Middlemas DS, Raid SW, Blair J, et al. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 1991; 65(5): 895-903.
10. Blum R, Kafitz KW, Konnerth A. Neurotrophin-evoked depolarization requires the sodium channel Na. Nature 2002; 419(6908): 687-93.
11. Chytrova G, Ying Z, Gomez‐Pinilla F. Exercise normalizes levels of MAG and Nogo‐A growth inhibitors after brain trauma. Eur J Neurosci 2008; 27(1): 1-11.
12. Molteni R, Ying Z, Gómez‐Pinilla F. Differential effects of acute and chronic exercise on plasticity‐related genes in the rat hippocampus revealed by microarray. Eur J Neurosci 2002; 16(6); 1107-16.
13. Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME. CREB: a major mediator of neuronal neurotrophin responses. Neuron 1997; 19(5): 1031-47.
14. Ebadi M, Bashir RM, Heidrick ML, Hamada FM, Refaey E, Hamed A. et al. Neurotrophins and their receptors in nerve injury and repair. Neurochem Int 1997; 30(4-5): 347-74.
15. Zoladz JA, Pilc A. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 2010; 61(5): 533-41.
16. Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, et al. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 2004; 101(29): 10827-32.
17. Neeper SA, Gomez-Pinilla F, Choi J, Cotman C. Exercise and brain neurotrophins. Nature 1995; 373(6510): 109.
18. Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Huang AM, et al. Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain‐derived neurotrophic factor and synaptotagmin I. J Physiol 2009; 587(Pt 13): 3221-31.
19. Oliff HS, Berchtold NC, Isackson P, Cotman CW. Exerciseinduced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Mol Brain Res 1998; 61(1-2): 147-53.
20. Oliff HS, Berchtold NC, Isackson P, Cotman CW. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Mol Brain Res 1998; 61(1-2): 147-53.
21. Berchtold NC, Chinn G, Chou M, Kesslak JP, Cotman CW. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience 2005; 133(3): 853-61.
22. Schmolesky MT, Webb DL, Hansen RA. The effects of aerobic exercise intensity and duration on levels of brain-derived neurotrophic factor in healthy men. J Sports Sci Med 2013; 12(3): 502-11.
23. Afzalpour ME, Chadorneshin HT, Foadoddini M, Eivari HA. Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiol Behav 2015; 147: 78-83.
24. Azuma K, Osawa Y, Tabata S, Horisawa S, Katsukawa F, Ishida H, et al. Association of serum BDNF concentration with high-intensity interval training. JPFSM 2015; 64(2): 227-32.
25. Huang AM, Jen CJ, Chen HF, Yu L, Kuo YM, Chen HI. Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor. J Neural Transm 2006; 113(7): 803-11.
26. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 2002; 328(3): 261-4.
27. Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity-exercise-induced response of peripheral brain-derived neurotrophic factor. Sports Med 2010; 40(9): 765-801.
28. Griffin EW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly AM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 2011; 104(5): 934-41.
29. Cunningham P, Geary M, Harper R, Pendleton AN, Stover S. High intensity sprint training reduces lipid peroxidation in fast-twitch skeletal muscle. JEPonline 2005; 8(6): 18-25.
30. Gold SM, Schulz KH, Hartmann S, Mladek M, Lang UE, Hellweg R, et al. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol 2003; 138(1-2): 99-105.
31. Vega SR, Strüder HK, Wahrmann BV, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res 2006; 1121(1): 59-65.
32. Tang SW, Chu E, Hui T, Helmeste D, Law C. Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett 2008; 431(1): 62-5.
33. Ferris LT, Williams JS, Shen CL. The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc 2007; 39(4): 728-34.
34. Huang AM, Jen CJ, Chen HF, Yu L, Kuo YM, Chen HI. Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor. J Neural Transm 2006; 113(7): 803-11.
35. Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, et al. Exercise Induces Hippocampal BDNF through a PGC-1a/FNDC5 Pathway. Cell Metab 2013; 18(5): 1-11.
36. Mounier R, Théret M, Lantier L, Foretz M, Viollet B. Expanding roles for AMPK in skeletal muscle plasticity. Trends Endocrinol Metab 2015; 26(6): 275-86.
37. Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Sports Med 2013; 43(5): 313-38.
38. Gold SM, Schulz KH, Hartmann S, Mladek M, Lang UE, Hellweg R, et al. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol 2003; 138(1-2): 99-105.
39. Rhodes JS, Van Praag H, Jeffrey S, Girard I, Mitchell GS, Garland Jr, et al. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci 2003; 117(5): 1006.
40. Gould E, Cameron HA, Daniels DC, Woolley CS, McEwen BS. Adrenal hormones suppress cell division in the adult rat dentate gyrus. J Neurosci 1992; 12(9): 3642-50.
41. Sapolsky RM. Potential behavioral modification of glucocorticoid damage to the hippocampus. Behav Brain Res 1993; 57(2): 175-82.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Skandari M, Nazemzadegan G H, Daryanosh F, Samadi M, Honarpisheh S, Hasanpor M. Comparative effect of single bout of continuous endurance and high intensity interval exercise on serum BDNF in rat . Feyz. 2016; 20 (2) :141-146
URL: http://feyz.kaums.ac.ir/article-1-3036-en.html


Volume 20, Issue 2 (Bimonthly 2016) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 3925