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:: Volume 20, Issue 1 (Bimonthly 2016) ::
Feyz 2016, 20(1): 33-40 Back to browse issues page
Assessing total antioxidant and malondialdehyde capacity in blood and brain of newborn rats following chronic exposure to 50 Hz and 900 MHz electromagnetic fields during the embryonic period
Jamal Amri, Mehdi Sadegh *, Behroz Mohammadi, Homa Soliemani, Heidar Farahani
Arak University of Medical Sciences , m.sadegh@arakmu.ac.ir
Abstract:   (2879 Views)

Background: In current study the consequence of chronic exposure of male and female rats to mobile-phone irradiation (900 MHz) and electromagnetic field (50 Hz) during the embryonic period on plasma and brain tissue total antioxidant capacity (TAC) and malondialdehyde (MDA) level were investigated.

Material and Methods: After fertilization, female rats (n=9) were randomly divided into three groups: Control, Mobile phone -exposure and Exposure to 50 Hz electromagnetic field using a solenoid (LF). In LF group, female rats were placed daily inside a solenoid (50 Hz and 1.5 mT) for 30 minutes until giving birth. In Mobile-phone group, female rats were kept in their home cage while mobile-phone was placed in standby mode under the cage and turned on to calling mode 30 minutes each day until giving birth. After parturition and milk feeding, female and male pups were divided into 6 separated groups to measure TAC and MDA taken from plasma and brain.

Results: In Control group the values of TAC and MDA for plasma and brain tissue showed no significant differences between the male and females rats. In addition, plasma TAC for Mobile-phone and LF groups showed no difference compared to Control. No significant difference was seen for plasma and brain MDA between the Mobile-phone and LF groups.

Conclusion: Our results revealed that chronic exposure to electromagnetic field during the embryonic period have no significant effect on brain and plasma TAC and MDA level.

Keywords: Electromagnetic field, Malondialdehyde, Mobile-phone irradiation, Total antioxidant capacity
Full-Text [PDF 206 kb]   (1648 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/04/12 | Accepted: 2016/04/12 | Published: 2016/04/12
References
1. Joseph W, Vermeeren G, Verloock L, Heredia MM, Martens L. Characterization of personal RF electromagnetic field exposure and actual absorption for the general public. Health Phys 2008; 95(3): 317-30.
2. Vermeeren G, Markakis I, Goeminne F, Samaras T ,Martens L, Joseph W. Spatial and temporal RF electromagnetic field exposure of children and adults in indoor micro environments in Belgium and Greece. Prog Biophys Mol Biol 2013; 113(2): 254-63.
3. Jelenkovic A, Janac B, Pesic V, Jovanovic MD, Vasiljevic I, Prolic Z. The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain. Ann N Y Acad Sci 2005; 1048: 377-80.
4. Jonai H, Villanueva MB, Yasuda A. Cytokine profile of human peripheral blood mononuclear cells exposed to 50 Hz EMF. Ind Health 1996; 34(4): 359-68.
5. Scassellati Sforzolini G, Moretti M, Villarini M, Fatigoni C, Pasquini R. Evaluation of genotoxic and/or co-genotoxic effects in cells exposed in vitro to extremely-low frequency electromagnetic fields. Ann Ig 2004; 16(1-2): 321-40.
6. Capri M, Scarcella E, Fumelli C, Bianchi E, Salvioli S, Mesirca P, et al. In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential. Radiat Res 2004; 162(2): 211-8.
7. Mohler E, Frei P, Frohlich J, Braun-Fahrlander C, Roosli M. Exposure to radiofrequency electromagnetic fields and sleep quality: a prospective cohort study. PLoS One 2012; 7(5): e37455.
8. Moquet J, Ainsbury E, Bouffler S, Lloyd D. Exposure to low level GSM 935 MHZ radiofrequency fields does not induce apoptosis in proliferating or differentiated murine neuroblastoma cells. Radiat Prot Dosimetry 2008; 131(3): 287-96.
9. Rosado MM, Nasta F, Prisco MG, Lovisolo GA, Marino C, Pioli C. Effects of GSM-modulated 900 MHz radiofrequency electromagnetic fields on the hematopoietic potential of mouse bone marrow cells. Bioelectromagnetics 2014; 35(8): 559-67.
10. Lai H, Singh NP. Magnetic-field-induced DNA strand breaks in brain cells of the rat. Environ Health Perspect 2004; 112(6): 687-94.
11. Lupke M, Rollwitz J, Simko M. Cell activating capacity of 50 Hz magnetic fields to release reactive oxygen intermediates in human umbilical cord blood-derived monocytes and in Mono Mac 6 cells. Free Radic Res 2004; 38(9): 985-93.
12. Coskun S, Balabanli B, Canseven A, Seyhan N. Effects of continuous and intermittent magnetic fields on oxidative parameters in vivo. Neurochem Res 2009; 34(2): 238-43.
13. Ferreira AR, Bonatto F, de Bittencourt Pasquali MA, Polydoro M, Dal-Pizzol F, et al. Oxidative stress effects on the central nervous system of rats after acute exposure to ultra high frequency electromagnetic fields. Bioelectromagnetic 2006; 27(6): 487-93.
14. Wu JQ, Kosten TR, Zhang XY. Free radicals, antioxidant defense systems, and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2013; 46: 200-6.
15. Kahya MC, Naziroglu M, Cig B. Selenium reduces mobile phone (900 MHz)-induced oxidative stress, mitochondrial function, and apoptosis in breast cancer cells. Biol Trace Elem Res 2014; 160(2): 285-93.
16. Niki E. Biomarkers of lipid peroxidation in clinical material. Biochim Biophys Acta 2014; 1840(2): 809-17.
17. Seifirad S, Farzampour S, Nourbakhsh M, Amoli MM, Razzaghy-Azar M, Larijani B. Effects of extremely low frequency electromagnetic fields on paraoxonase serum activity and lipid peroxidation metabolites in rat. J Diabetes Metab Disord 2014; 13(1): 85.
18. Sies H. Strategies of antioxidant defense. Eur J Biochem 1993; 215(2): 213-9.
19. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160(1): 1-40.
20. Guler G, Turkozer Z, Ozgur E, Seyhan N. Antioxidants alleviate electric field-induced effects on lung tissue based on assays of heme oxygenase-1, protein carbonyl content, malondialdehyde, nitric oxide, and hydroxyproline. Sci Total Environ 2009; 407(4): 1326-32.
21. Li L, Xiong DF, Liu JW, Li ZX, Zeng GC, Li HL. A cross-sectional study on oxidative stress in workers exposed to extremely low frequency electromagnetic fields. Int J Radiat Biol 2015; 91(5): 420-5.
22. Aydin B, Akar A. Effects of a 900-MHz electromagnetic field on oxidative stress parameters in rat lymphoid organs, polymorphonuclear leukocytes and plasma. Arch Med Res 2011; 42(4): 261-7.
23. Ragy MM. Effect of exposure and withdrawal of 900-MHz-electromagnetic waves on brain, kidney and liver oxidative stress and some biochemical parameters in male rats. Electromagn Biol Med 2015; 34(4): 279-84.
24. Bilgici B, Akar A, Avci B, Tuncel OK. Effect of 900 MHz radiofrequency radiation on oxidative stress in rat brain and serum. Electromagn Biol Med 2013; 32(1): 20-9.
25. Demirel S, Doganay S, Turkoz Y, Dogan Z, Turan B, Firat PG. Effects of third generation mobile phone-emitted electromagnetic radiation on oxidative stress parameters in eye tissue and blood of rats. Cutan Ocul Toxicol 2012; 31(2): 89-94.
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Amri J, Sadegh M, Mohammadi B, Soliemani H, Farahani H. Assessing total antioxidant and malondialdehyde capacity in blood and brain of newborn rats following chronic exposure to 50 Hz and 900 MHz electromagnetic fields during the embryonic period. Feyz. 2016; 20 (1) :33-40
URL: http://feyz.kaums.ac.ir/article-1-2970-en.html


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