Background: S.aureus related infections are prevalent and their resistance to routine antibiotics made their management a little difficult. The present study was corrected pit to determine the pattern of S.aureus susceptibility and resistance to antibiotics in clinic [6 month period in 1998 in Kashan].

Materials and Methods: For this descriptive study, 7 subjects whose cultures were positive for S.aureus, included. Samples were cultured on standard, media standard techniques. Antibiotics resistance was achieved by disk diffusion method.

Results: Of 76 samples the antibiotic resistance profile was as below: Oxacillin 96.1%, cloxacillin 63.2%, cephalotin 23.7% and vancomycin 18.4%.

Conclusion: S.aureus is relatively resistance to oxacillin and cloxacillin in Kashan. Fourteen analytical studies are strongly recommended with special attention an age, sex and previous drug regimen.