Background: An increase in the level of inflammatory markers such as C-reactive protein (CRP) and metabolic profile are associated with increased cardiovascular diseases and are common in patients with type 2 diabetes. This study aimed to examine the interactive effect of aerobic training and resveratrol supplementation on CRP and metabolic profiles in women with type 2 diabetes.

Materials and Methods: Twenty-seven women with type 2 diabetes­ (mean age of 27.9 years old, the fat percentage of 35.7% and BMI 28.3 kg.m²) were randomly assigned to three groups: aerobic training, aerobic exercise with supplements, and control. The first and second experimental groups performed aerobic exercise for 8 weeks, 3 sessions per week, with 60%-75% of maximum heart rate in each session for 40-50 minutes. The second group in addition to aerobic exercise received 400 mL of resveratrol supplement daily for 60 days. Changes in the indices, ­including CRP, LDL-C, HDL-C, fasting blood glucose, atherogenic index, total cholesterol, triglycerides and risk of coronary heart disease (CHD) were measured before and 48 hours after the last session.

Results: No significant reduction was found in the mean CRP level in the second group (P=0.123). Also, combination of resveratrol supplement and aerobic training significantly reduced fasting blood glucose­ (P=0.008), LDL-C (P=0.002), and atherogenic index­ (P=0.001), and significantly increased HDL-C­ (P=0.03), while it had no significant effect on total cholesterol ­(P=0.25), triglycerides ­(P=0.88) and risk of CHD ­(P= 0.14).

Conclusion: Aerobic exercise along with resveratrol supplement seems to be a useful method for prevention and control of cardiovascular diseases and improving health in women with type 2 diabetes.