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:: Volume 19, Issue 3 (Bimonthly 2015) ::
Feyz 2015, 19(3): 190-196 Back to browse issues page
Histological evaluation of the effect of petroleum ether root extract ointment of Onosma dichroanthum Boiss on open skin wound healing in rat
Zahra Amirkhani *, Mohsen Norouzian, Abbas Piryaei, Seyyed Abdolmajid Ayatollahi, Soraya Saremi, Masoumeh Dadpay
International Branch of Shahid-Beheshti University of Medical Sciences , amirkhani_z@yahoo.com
Abstract:   (3831 Views)

Background: Onosma dichroanthum Boiss. belongs to the Boraginaceae family and is one of the most important medicinal plants in north of Iran. This study aimed to examine the effect of the petroleum ether root extract ointment of Onosma dichroanthum Boiss. on healing of a surgically induced open skin wound in rats.

Materials and Methods: In this study, 54 male adult Wistar rats were randomly allocated into control, vehicle, and experimental groups. A 20-mm cephalocaudal incision was made on the back skin of rats. Rats were sacrificed on days 4, 7 and 14 and histological examination (the number of fibroblasts, neutrophil, blood vessel sections and thickness of epiderm) was performed on skin samples.

Results: On day 4, the number of fibroblasts was significantly increased in the experimental group compared to the vehicle (P<0.003) and control (P<0.001) groups. On day 7, no significant difference was seen in the number of fibroblasts in the experimental group compared to the vehicle group (P<0.680) and fibroblasts were significantly increased in the experimental and vehicle groups compared to the control (P<0.001). On day 14, fibroblasts were significantly increased in the experimental and control groups compared to the vehicle (P<0.001) and there was no significant difference in the number of fibroblasts in the experimental group compared to the control (P<0.843). Also, no significant difference was seen in the number of neutrophils, blood vessel sections and thickness of epiderm on days 4, 7 and 14 among the groups.

Conclusion: Topical application of the petroleum ether root extract of onosma dichroanthum Boiss. has no significant effect on the healing of skin wound in rats.

Keywords: Onosma dichroanthum Boiss, Wound healing, Cell count, Histology, Rat
Full-Text [PDF 245 kb]   (1198 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2015/07/5 | Accepted: 2015/07/5 | Published: 2015/07/5
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Amirkhani Z, Norouzian M, Piryaei A, Ayatollahi S A, Saremi S, Dadpay M. Histological evaluation of the effect of petroleum ether root extract ointment of Onosma dichroanthum Boiss on open skin wound healing in rat . Feyz. 2015; 19 (3) :190-196
URL: http://feyz.kaums.ac.ir/article-1-2692-en.html


Volume 19, Issue 3 (Bimonthly 2015) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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