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:: Volume 19, Issue 2 (Bimonthly 2015) ::
Feyz 2015, 19(2): 102-110 Back to browse issues page
The effect of methylprednisolone on spatial learning and memory in adult male rats using an experimental model of Alzheimer’s disease
Sedigheh Ashkavandi *, Ahmad Ali Moazedi, Saeed Semnanian, Homan Eshagh-Harooni, Tayebeh Mohammadi, Mehdi Pourmehdi-Brojeni
Shahid Chamran University , s_bio84@yahoo.com
Abstract:   (3323 Views)

Background: The methylprednisolone (MP) is a synthetic glucocorticoid steroid initially developed for its enhanced anti-inflammatory activity. The present study aimed to examine the effect of MP on the spatial learning and memory in an experimental model of Alzheimer’s disease in rats.

Materials and Methods: Male rats were allocated into five groups: control group lesion group which received electrically-induced lesion (0.5 mA, 3s) in the nucleus basalis magnocellularis (NBM) to create Alzheimer’s model sham group (the electrode was impaled into the NBM with no lesion) MP group (lesion+30 mg/kg MP) and saline group (lesion NBM + 0.2 mL saline). After one week, the rats were trained to perform the Y-maze task for five days. The animals were tested for spatial memory one month later.

Results: Results showed that the bilateral lesion of NBM impaired the spatial learning compared to the control group (P<0.01). The administration of MP significantly improved spatial learning of rats with the Alzheimer’s disease (P<0.001). Moreover, no effect on spatial learning was seen in the sham group compared with the lesion group. No significant difference was observed between the results in the 5th day of training and the memory test after one month.

Conclusion: Administration of MP can be an effective treatment for the Alzheimer’s disease.

Keywords: Methylprednisolone, Spatial learning, Nucleus basalis of Meynert, Glucocorticoid, Alzheimer’s dementia
Full-Text [PDF 316 kb]   (823 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2015/05/21 | Accepted: 2015/05/21 | Published: 2015/05/21
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Ashkavandi S, Moazedi A A, Semnanian S, Eshagh-Harooni H, Mohammadi T, Pourmehdi-Brojeni M. The effect of methylprednisolone on spatial learning and memory in adult male rats using an experimental model of Alzheimer’s disease. Feyz. 2015; 19 (2) :102-110
URL: http://feyz.kaums.ac.ir/article-1-2635-en.html


Volume 19, Issue 2 (Bimonthly 2015) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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