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:: Volume 19, Issue 2 (Bimonthly 2015) ::
Feyz 2015, 19(2): 94-101 Back to browse issues page
Cytotoxic effect of magnetic iron oxide nanoparticles coated with seaweed aqueous extract against ovarian cancer cells
Farideh Namvar, Javad Baharara *, Elaheh Amini, Mahnaz Mahdavi
Mashhad Branch, Islamic Azad University , baharara@yahoo.com
Abstract:   (3083 Views)

Background: Iron oxide nanoparticles are one of the most efficient metal nanoparticles, which have prominent properties in biomedical applications. In previous studies, these nanoparticles were prepared using a green synthesis method with the aqueous extract of brown seaweed (Sargassum muticum). This study aimed to examine the cytotoxic effect of these synthesized nanoparticles on A2780cp ovarian cancer cells which indicate resistance to chemotherapy regimen.

Materials and Methods: The cytotoxic effect of synthesized nanoparticles on A2780cp ovarian cancer cells were examined using the methylthiazol tetrazolium assay, acridine orange/ propodium iodide and caspase assay.

Results: Results indicated that Fe3O4 nanoparticles encapsulated in seaweed water extract possess a cytotoxic effect on ovarian cancer cells resistant to chemotherapy (IC50 values of 250 µg/ml, 125 µg/ml and 62.5µg/ml for 24, 48 and 72 h, respectively). The nanoparticles through the induction of caspase-3 and -9 dependent apoptosis (intrinsic pathway) significantly exerted a cytotoxic effect against A2780cp ovarian cancer cells.

Conclusion: The aqueous extract of brown seaweed is an appropriate candidate for stability and reduction of colloidal solution of iron oxide nanoparticles. Due to the apoptotic effect of this extract on A2780cp ovarian cancer cells, it can be a good choice for ovarian cancer treatment.

Keywords: Iron oxide nanoparticles, Seaweed, Cytotoxic effect, Ovarian cancer
Full-Text [PDF 315 kb]   (1543 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2015/05/9 | Accepted: 2015/05/9 | Published: 2015/05/9
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Namvar F, Baharara J, Amini E, Mahdavi M. Cytotoxic effect of magnetic iron oxide nanoparticles coated with seaweed aqueous extract against ovarian cancer cells. Feyz. 2015; 19 (2) :94-101
URL: http://feyz.kaums.ac.ir/article-1-2601-en.html


Volume 19, Issue 2 (Bimonthly 2015) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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