[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Biochemistry and Nutrition in Metabolic Diseases
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 19, Issue 2 (Bimonthly 2015) ::
Feyz Med Sci J 2015, 19(2): 118-126 Back to browse issues page
Morphological changes of the hippocampal astrocytes at different phases of the estrous cycle in female mice
Mohammad Taghi Ghorbanian * , Mohammad Ghorbanian , Majid Sadrollahi
Damghan University , ghorbanian@du.ac.ir
Abstract:   (4718 Views)

Background: Usual fluctuations of sex hormones during the estrous cycle in female mice affect the hippocampal neurogenesis. The hippocampus also comprises many steroid receptors suggesting the modulatory effects of gonadal hormones on the hippocampal plasticity. Sex differences at the level of structure and function of the hippocampus are mostly due to the fluctuations of steroid hormones during the estrous cycle. The purpose of this study was to investigate the morphological changes in hippocampal astrocytes and also the expression of glial fibrillary acidic protein (GFAP) at different phases of the estrous cycle.

Materials and Methods: In this study, different stages of the estrous cycle were determined in 6-8 week NMRI female mice by methylene blue-stained vaginal smears. The morphological changes of astrocytes in the hippocampus were investigated using GFAP immunohistochemistry. In addition to the morphological study, the expression of astrocytic marker was quantitatively evaluated.

Results: GFAP immunostaining showed the changes in the morphology of astrocytes and also in the serum level of estrogen during the estrous cycle. The highest concentrations of estrogen and GFAP reactivity were observed in the proestrus stage.

Conclusion: Different stages of the estrous cycle in female mice were associated with morphological changes of hippocampal astrocytes and the alternation in the serum level of estrogen.

Keywords: Astrocytes, Hippocampus, Estrous cycle, Neurogenesis
Full-Text [PDF 1103 kb]   (2241 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2015/05/5 | Revised: 2015/06/1 | Accepted: 2015/05/5 | Published: 2015/05/5
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghorbanian M T, Ghorbanian M, Sadrollahi M. Morphological changes of the hippocampal astrocytes at different phases of the estrous cycle in female mice. Feyz Med Sci J 2015; 19 (2) :118-126
URL: http://feyz.kaums.ac.ir/article-1-2589-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 19, Issue 2 (Bimonthly 2015) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4660