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Comparing the effects of the aqueous extract of Aloe vera and Na+ Nitroprusside on the contraction of rat isolated thoracic aorta
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Fatemeh Khodaei   , Azam Mesdaghinia , Gholam Ali Hamidi , Mehdi Noureddini |
| Kashan University of Medical Sciences , mnoureddini@kaums.ac.ir |
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Abstract: (4453 Views) |
Background: Aloe vera is used in traditional medicine to treat hypertension. The purpose of this study was to examine the effect of the aqueous extract of Aloe vera (compared to Na+ nitroprusside) on the contraction of the rat isolated thoracic aorta precontracted with 20 mM potassium chloride.
Materials and Methods: In this study, 18 rings isolated from the thoracic aorta of 9 Wistar rats (250-300g) were divided into three groups. On the loaded tissue, a tension less than 2 g was applied which then was precontracted with potassium chloride (20mM) in organ bath containing the carbogen-Krebs solution. Changes in aorta contractility in response to cumulative application of vehicle (group I), extract (group II: 5-50 mg/ml) and Na+ Nitroprusside (group III: 0.0001-10 μM) were measured isometrically.
Results: The results showed that although Aloe vera has a decreasing effect on the contraction induced by potassium chloride (20mM), this effect was less than the cumulative effect of Na+ nitroprusside (P<0.05).
Conclusion: The possible antihypertensive mechanism of Aloe vera may be for reducing the contractility of vascular smooth muscle and this effect is weaker than the effect of nitroprusside. Hence, Aloe vera can be used as a potential drug for lowering the high blood pressure. |
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| Keywords: Thoracic aorta, Isolated tissue, Rat, Aqueous extract, Aloe vera, Na+ nitroprusside |
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Full-Text [PDF 266 kb]
(1182 Downloads)
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2015/01/3 | Revised: 2015/01/7 | Accepted: 2015/01/3 | Published: 2015/01/3
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