[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 18, Issue 4 (Bimonthly 2014) ::
Feyz 2014, 18(4): 361-368 Back to browse issues page
The involvement of adrenergic system in the anxiolytic effect of hydro-alcoholic extract of Valeriana officinalis in male mice
Lotfollah Khajehpour *, Seyyedeh Fatemeh Moosapour, Seyyed Mansour Seyyednejad
Shahid Chamran University of Ahvaz
Abstract:   (2511 Views)

Background: Previous studies have shown that valerian extracts induces anxiolytic and sedative effects via the interference with GABAergic system. Since, central adrenergic system plays an important role in the anxiety-related behaviors, this study aimed to investigate the involvement of this system in the anxiolytic effect of hydro-alcoholic extract of Valeriana officinalis in adult male mice.

Materials and Methods: In this study, 63 mice were randomly divided into seven groups. Anxiety-related behaviors of mice were evaluated using the elevated plus maze by recording of the percentage of time the mice spent in the open arm and percentage of open arm entry. All drugs (saline, valeriana extract and epinephrine) were injected intraperitoneally 30 minutes before the test of anxiety.

Results: The valeriana extract decreased the anxiety-related behavior by increasing the percentage of time spent in the open arm and percentage of open arm entry. Epinephrine, when injected before the extract, decreased the anxiolytic effect of valeriana extract, whereas the same dose of epinephrine alone did not have any significant effect on the anxiety.

Conclusion: It seems that the central adrenergic mechanisms may probably involve in the effect of hydro-alcoholic extract of valeriana on the reduction of the anxiety-related behaviors in mice.

Keywords: Adrenergic, Anxiety, Valeriana
Full-Text [PDF 343 kb]   (731 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2014/08/26 | Accepted: 2014/08/26 | Published: 2014/08/26
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khajehpour L, Moosapour S F, Seyyednejad S M. The involvement of adrenergic system in the anxiolytic effect of hydro-alcoholic extract of Valeriana officinalis in male mice . Feyz. 2014; 18 (4) :361-368
URL: http://feyz.kaums.ac.ir/article-1-2344-en.html


Volume 18, Issue 4 (Bimonthly 2014) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3925