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:: Volume 18, Issue 4 (Bimonthly 2014) ::
Feyz 2014, 18(4): 292-307 Back to browse issues page
Non-invasive treatment of advanced atherosclerotic stenosis in the rabbit carotid artery using low-level combined dual- frequency ultrasonication
Hosein Mehrad, Manijeh Mokhtari-Dizaji *, Hosein Ghanaati
Tarbiat Modares University , mokhtarm@modares.ac.ir
Abstract:   (3006 Views)

Background: The present study aimed to investigate the effect of low-level combined dual- frequency of 1 MHz and 150 kHz ultrasonication on fibro-lipid plaque with neovascularization in the rabbit common carotid artery.

Materials and Methods: In this experimental study, the common carotid arteries in 17 rabbits were injured perivascularly by liquid nitrogen, followed by a 1.5% cholesterol-rich diet for eight weeks. The animals were randomly divided into three groups including A: a cholesterol-rich diet (n=7) and evaluation at eighth week, B: control and discontinuation of cholesterol-rich diet (n=5) and evaluation at twelfth week and C: low-level combined dual- frequency ultrasonication and discontinuation of cholesterol-rich diet (n=7) and evaluation at twelfth week. Blood volume flow and blood mean velocity were measured by color Doppler ultrasonography. Moreover, mean wall thickness and percentage of luminal cross-sectional area of stenosis were measured by B-mode ultrasonographic and histological methods in the stenotic region of the common carotid artery.

Results: Results showed a significant reduction in the mean value for blood peak systolic pressure, blood mean pressure, blood mean velocity, mean wall thickness and percentage of luminal cross-sectional area of stenosis and a significant increase in the mean value for blood peak diastolic pressure and blood volume flow in group C compared with the other groups (P<0.05).

Conclusion: Enhanced inertial cavitation effect of low-level combined dual- frequency ultrasonication can cause the degradation of the microvessels and the fibro-lipid content, lipolysis and thrombolysis in the plaque and significantly dilate the luminal cross-sectional area of stenosis.

Keywords: Doppler ultrasonography, Carotid atherosclerosis, Low-level dual frequency ultrasonication, Cavitation, Histology
Full-Text [PDF 862 kb]   (1096 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2014/08/23 | Accepted: 2014/08/23 | Published: 2014/08/23
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Mehrad H, Mokhtari-Dizaji M, Ghanaati H. Non-invasive treatment of advanced atherosclerotic stenosis in the rabbit carotid artery using low-level combined dual- frequency ultrasonication. Feyz. 2014; 18 (4) :292-307
URL: http://feyz.kaums.ac.ir/article-1-2338-en.html


Volume 18, Issue 4 (Bimonthly 2014) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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