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:: Volume 18, Issue 3 (Bimonthly 2014) ::
Feyz 2014, 18(3): 194-200 Back to browse issues page
Effect of alcoholic extract of Euphorbia cyparissias on the brain antioxidant enzymes in streptozotocin-induced diabetic male rats
Mohammad Reza Nasirzadeh *, Alireza Nourazar, Soheil Khalili-Moghadam, Mohammad Mohammadiani
Tabriz Branch, Islamic Azad University , mr.nasirzadeh@iaut.ac.ir
Abstract:   (3553 Views)

Background: Diabetes is a chronic disease characterized by metabolic disorders of proteins, fats and carbohydrates. Long-term use of the blood glucose lowering drugs can cause side effects. The purpose of this study was to examine the effect of the alcoholic extract of E. cyparissias on the level of brain antioxidant enzymes in streptozotocin-induced diabetic male rats.

Materials and Methods: In this study, 40 adult male Wistar rats (250±20 gr) were divided randomly into 4 groups: 1) control 2) streptozotocin-induced diabetic 3) treatment1: received 500 mg/kg of the extract and 4) treatment 2: received 250 mg/kg of the extract. The two treatment groups received the alcoholic extract through gastric gavages for 21 days. At the end of the treatment, the blood glucose and levels of brain antioxidant enzymes (TAC, MDA, SOD and GPX) were determined.

Results: Results showed that the MDA level was significantly increased in brain tissue in the diabetic group compared to the control group (P=0.001). Furthermore, the levels of TAC, SOD and GPX were significantly decreased in brain tissues in the diabetic group compared to the control group (P=0.001). Similar results were obtained for the blood glucose level.

Conclusion: It can be concluded that oral administration of E. cyparissias alcoholic extract has the antidiabetic and antioxidant activities in the streptozotocin-induced diabetic rats.

Keywords: E. cyparissias extract, Antioxidant activity, Brain tissue, Diabetes, Male rat
Full-Text [PDF 267 kb]   (1136 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2014/06/8 | Accepted: 2014/06/8 | Published: 2014/06/8
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Nasirzadeh M R, Nourazar A, Khalili-Moghadam S, Mohammadiani M. Effect of alcoholic extract of Euphorbia cyparissias on the brain antioxidant enzymes in streptozotocin-induced diabetic male rats. Feyz. 2014; 18 (3) :194-200
URL: http://feyz.kaums.ac.ir/article-1-2282-en.html


Volume 18, Issue 3 (Bimonthly 2014) Back to browse issues page
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