Background: Cancer as a global problem can affect different aspects of a patient’s life. The number of people of all ages suffering from cancer is increasing. Psychological problems and reduction in quality of life are the most important issues among cancer patients. Therefore, the purpose of this study was to determine the effect of life review with spiritual approach on the life quality in cancer patients.

Materials and Methods: This clinical trial study was performed on 80 cancer patients in Kashan. Patients were randomly assigned to the two equal groups: the experimental and control groups. The quality of life questionnaire, EORTC QLQ - C30, was completed for both groups before the intervention. Then, six sessions of individual counseling on life review therapy with spiritual approach were held for the experimental group. One week after the last session, the quality of life questionnaire (EORTC QLQ - C30) was completed for both groups again.

Results: The mean quality of life scores changed from 27.5 in pretest to 75 in posttest for the experimental group, and from 33.75 in pretest to 21.87 in post-test for the control group. According to the results, the quality of life in the experimental group has significantly increased after the implementation of life review.

Conclusion: Life review therapy with spiritual approach can improve quality of life in cancer patients. Therefore, this treatment can be used as an effective way to improve the life quality of these patients.