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:: Volume 17, Issue 6 (Bimonthly 2014) ::
Feyz 2014, 17(6): 522-527 Back to browse issues page
Role of endogenous opioids in nociception among male and different phases of the mice estrous cycle
Mahnaz Kesmati *, Sedigheh Abbasi, Mozhgan Torabi
Shahid Chamran University of Ahvaz , m.kesmati@scu.ac.ir
Abstract:   (3751 Views)

Background: Sexual hormones can change nociception in males and females. There are few information about the role of sex hormones on nociception. The aim of this study was to evaluate the effect of endogenous opioids on nociception in male mice compared with female mice during different phases of the estrous cycle (proestrus, estrus, metestrus and diestrus).

Materials and Methods: In this study, adult male and female mice (in different phases of estrous cycle (weighing 30±3gr were assigned to the control group, vehicle and naloxone (3mg/kg, i.p.) groups. In all groups analgesia time was evaluated by hotplate test.

Results: Analgesia time in diestrus phase of control and vehicle groups of female rats was more than the other phases and different from the estrus phase (P<0.05) and male (P<0.001) groups. In the naloxone group, there was a significant reduction in analgesia time among males (P<0.001) and also in the proestrus, estrus, metestrus, diestrus phases (P<0.001, P<0.05, P<0.001, P<0.001, respectively) among females. Moreover, in the naloxone group, a significant difference was seen in analgesia time in male mice compared with females in proestrus and diestrus phases (P<0.05).

Conclusion: It seems that the effects of sex hormones in male and female mice on pain perception mechanisms can be mediated by endogenous opioids.

Keywords: Hot plate test, Pain, Opioidergic system, Estrus cycle, Mouse
Full-Text [PDF 187 kb]   (1047 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2013/11/28 | Accepted: 2013/11/28 | Published: 2013/11/28
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Kesmati M, Abbasi S, Torabi M. Role of endogenous opioids in nociception among male and different phases of the mice estrous cycle. Feyz. 2014; 17 (6) :522-527
URL: http://feyz.kaums.ac.ir/article-1-2102-en.html

Volume 17, Issue 6 (Bimonthly 2014) Back to browse issues page
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