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:: Volume 17, Issue 4 (Bimonthly 2013) ::
Feyz 2013, 17(4): 345-351 Back to browse issues page
Role of capsaicin receptors in periaqueductal gray on pain modulation in diabetic rats
Talieh Shirafkan *, Abdolrahman Sarihi, Alireza Komaki
Islamic Azad University, Hamedan Branch , Tt_shirafkan@yahoo.com
Abstract:   (3697 Views)

Background: Numerous studies have shown the presence of capsaicin (CAP) receptors in periaqueductal gray (PAG) area. The aim of this study was to examine the role of CAP receptors in PAG on pain modulation in diabetic neuropathic (NP) rats.

Materials and Methods: This experimental study was carried out on 24 male rats in 4 groups (n=6): normal – saline normal – capsaicine NP - saline and NP - capsaicine. To investigate the effect of intra-PAG injection of capsaicin (10 nmol/ul) or saline on pain modulation, tail flick (TF), hot plate and Von frey tests were used. To induce NP, a single dose of streptozotocin (55 mg/kg, i.p) was injected.

Results: In normal rats, 5 and 15 min after the injection into PAG, CAP showed an analgesic effect in TF test (P<0.001), but no analgesic effect in NP rats. Moreover, CAP had neither effect on pain induction in normal rats in thermal (Hot plate) and tactile (Von frey) stimulus nor on allodynia in NP rats.

Conclusion: It seems that in NP rats, CAP injection into PAG had no effect on pain modulation.

Keywords: Periaqueductal gray area, Diabetic neuropathy, Pain, Capsaicin
Full-Text [PDF 396 kb]   (1195 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2013/08/20 | Accepted: 2013/09/4 | Published: 2013/09/4
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Shirafkan T, Sarihi A, Komaki A. Role of capsaicin receptors in periaqueductal gray on pain modulation in diabetic rats . Feyz. 2013; 17 (4) :345-351
URL: http://feyz.kaums.ac.ir/article-1-2018-en.html


Volume 17, Issue 4 (Bimonthly 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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