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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 777-778 Back to browse issues page
Effect of multi mineral-vitamin D supplementation on metabolic profiles, hs-CRP and oxidative stress in pregnant women at risk for pre-eclampsia: a randomized controlled clinical trial
Zatollah Asemi *, Mansooreh Samimi, Zohreh Tabassi, Hosein Shakeri, Syma Sadat Sabihi, Maryam Borojerdi-Alavi, Zahra Jafari, Fatemeh Motaharian, Zahra Heidarzadeh, Yaser Ghandi
Kashan University of Medical Sciences , asemi_za@kaums.ac.ir
Abstract:   (5548 Views)

Background: The purpose of this study was to determine the favorable effects of multi mineral-vitamin D supplementation on metabolic profiles, serum hs-CRP and biomarkers of oxidative stress among Iranian pregnant women at risk for pre-eclampsia.

Materials and Methods: This randomized single-blind controlled clinical trial was conducted among 48 pregnant women, primigravida, at risk for pre-eclampsia aged 18-40 years at their third trimester. Pregnant women were randomly assigned to receive either the multi mineral-vitamin D supplements (n=24) or the placebo (n=24) for 9 weeks. Fasting blood samples were taken at baseline and after 9 weeks of intervention to measure metabolic profiles, hs-CRP and oxidative stress parameters.

Results: Consumption of multi mineral-vitamin D supplements as compared to the placebo resulted in a significant decrease in FPG (-11.7 vs. -2 mg/dL, P=0.01), serum insulin levels (-0.96 vs. 2.65 µIU/ml, P=0.04) and a marginally significant decrease in HOMA-IR (-0.34 vs.0.6, P=0.06). Also, multi mineral-vitamin D supplementation resulted in a significant decrease in serum hs-CRP levels as compared to the placebo (-1411.7 vs. 1503 ng/ml, P=0.01). Moreover, the mean changes for plasma TAC (151.94 vs. -19.69 mmol/l, P=0.002) and total GSH levels (205.82 vs. -32.3 µmol/l, P=0.02) were significantly different between the two groups.

Conclusion: In conclusion, consumption of multi mineral-vitamin D supplements for 9 weeks during pregnancy among pregnant women at risk for pre-eclampsia resulted in a significant decrease in FPG, serum insulin, hs-CRP and increased levels of plasma TAC and total GSH as compared to the placebo group.

Keywords: Supplementation, Metabolic profiles, Hs-CRP, Oxidative stress, Pre-eclampsia
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Type of Study: Research | Subject: General
Received: 2013/03/5
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Asemi Z, Samimi M, Tabassi Z, Shakeri H, Sabihi S S, Borojerdi-Alavi M, et al . Effect of multi mineral-vitamin D supplementation on metabolic profiles, hs-CRP and oxidative stress in pregnant women at risk for pre-eclampsia: a randomized controlled clinical trial. Feyz. 2013; 16 (7) :777-778
URL: http://feyz.kaums.ac.ir/article-1-1859-en.html


Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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