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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 765-766 Back to browse issues page
A randomized controlled clinical trial evaluating the effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia
Zatollah Asemi *, Batol Sadat Razavi, Zeynab Ebrahimi, Zahra Baniahmadi, Samaneh Salehi, Farideh Nazemi, Akram Khassaf, Esmat Nori
Kashan University of Medical Sciences , asemi_r@yahoo.com
Abstract:   (7390 Views)

Background: The objective of this study was to determine the favorable effects of multi mineral-vitamin D supplementation on pregnancy outcomes among pregnant women at risk for pre-eclampsia.

Materials and Methods: This randomized single-blind controlled clinical trial was conducted among 46 pregnant, primigravida, women at risk for pre-eclampsia (aged 18-40 years) at their third trimester. Pregnant women were randomly assigned to receive either the multi mineral-vitamin D supplements (n=23) or the placebo (n=23) for 9 weeks. Fasting blood samples were taken at baseline and after applying a 9-wk intervention to measure serum calcium, magnesium, zinc, iron and 25-hydroxy vitamin D. Newborn's measurements (weight, height and head circumference) were determined.

Results: Although no significant difference was seen in newborn's weight and head circumference between the two groups, mean of newborn's length (51.3±1.7 vs. 50.3±1.2 cm, P=0.03) among the newborn's whose mothers were receiving multi mineral-vitamin D supplements were taller than those whose mothers received placebo. As compared to the placebo, consumption of multi mineral-vitamin D supplements also resulted in increased levels of serum calcium (+0.19 vs. -0.08 mg/dL, P=0.03), magnesium (+0.15 vs. -0.08 mg/dL, P=0.03), zinc (+8.25 vs. -21.38 mg/dL, P=0.001) and vitamin D (+3.79 vs. -1.37 ng/ml, P=0.01).

Conclusion: In conclusion, multi mineral-vitamin D supplementation for 9 weeks during pregnancy and in pregnant women at risk for pre-eclampsia resulted in increase of newborn's height, increased circulating levels of maternal serum calcium, magnesium, zinc and vitamin D as compared to the placebo group.

Keywords: Supplementation, Pregnancy outcomes, Pre-eclampsia
Full-Text [PDF 121 kb]   (3744 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2013/03/5
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Asemi Z, Razavi B S, Ebrahimi Z, Baniahmadi Z, Salehi S, Nazemi F, et al . A randomized controlled clinical trial evaluating the effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia. Feyz. 2013; 16 (7) :765-766
URL: http://feyz.kaums.ac.ir/article-1-1853-en.html


Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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