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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 755-760 Back to browse issues page
Comparing the effects of Aluminum and Cadmium on liver parameters
Shiva Najafi *, Masihollah Taher, Sayyed Ali Asghar Moshtaghie
Islamic Azad University , Shivanajafi7@Gmail.com
Abstract:   (4951 Views)

Background: In this study, the effects of Aluminum and Cadmium on liver parameters (LDH, AST, ALT, serum bilirubin, total protein) in rat serum at various times have been studied.

Materials and Methods: Aluminum and cadmium salts in different doses were injected. After the completion of injection in different times, the animals were decapitated and the serum was used for liver enzymes.

Results: Aluminum effect on LDH was concentration- and time- dependent. The activity of aminotransferases AST, ALT showed less increase than the short-term effects of aluminum. The serum total bilirubin was significantly increased, whereas serum protein concentration is negligible. With regard to Cadmium, the increased activity of serum LDH was concentration- and time dependent. So, the lower concentrations of Cadmium had much more changes compared to Aluminum. Total bilirubin concentration and serum protein were similar to the increase in Cadmium concentration and the time of injection. The activity of aminotransferases AST, ALT was found to be increased by increase in the levels of cadmium.

Conclusion: In general, both Aluminum and Cadmium are toxic to hepatic cells and cause physiologic and morphologic changes in hepatocytes which are functions of concentration. In linger periods, the increase in hepatic parameters is significant.

Keywords: AL, Cd, LDH, AST, ALT, Total bilirubin
Full-Text [PDF 95 kb]   (941 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2013/03/5 | Published: 2013/03/15
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Najafi S, Taher M, Moshtaghie S A A. Comparing the effects of Aluminum and Cadmium on liver parameters. Feyz. 2013; 16 (7) :755-760
URL: http://feyz.kaums.ac.ir/article-1-1850-en.html

Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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