Background: The anti-bacterial property of silver nanoparticles has been led to increasing use of nanoparticles in medicine, appliances and electronic products. The aim of this study was to assess renal injury using sensitive biomarkers for kidney damage.

Materials and Methods: In this study, 40 adult male Wistar rats were injected by nanosilver (50, 100, 200 and 400ppm). Then blood samples were collected and tissue samples from the liver were prepared and studied with silver staining. ANOVA with a P<0.05 was considered for analysis of data.

Results: Results showed that different concentrations of urea (P=0.867), creatine (P=0.279) and uric acid (P=0.999) silver nanoparticles on the rate of change has no significant impact. The histological changes in 400 PPm dose of silver nanoparticles can be seen compared with the control group, which probably reflects histological changes in the kidney.

Conclusion: Due to the increased use of products containing nanosilver and for the generalization of the findings of this study can be used in the medical field.