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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 729-730 Back to browse issues page
Serum-Selenium level in patients with Down's syndrome using the graphite furnace atomic absorption spectroscopy
Mojtaba Amiri *
Atomic Energy Organization of Iran , M.amiri60@gmail.com
Abstract:   (3820 Views)

Background: In recent years, the need for more accurate determination of trace elements has been increasing in biological research. This study aimed to compare the serum-Selenium level in patients with Down's syndrome (DS) and the healthy control group.

Materials and Methods: In this study, the quality control samples were determined using a graphite furnace atomic absorption spectroscopy (GF-AAS) in both the patients and control group.

Results: Down syndrome patients showed lower level of selenium in serum (74.2 ± 1.47 µg L-1) compared to that of the healthy control group (84.7 ± 1.63 µg L-1). The mean difference of both groups (t= 3.15) was statistically significant (P<0.001) suggesting that the patients has a decreased serum-Selenium level compared to the healthy group.

Conclusion: Results of this study indicate that selenium plays an important role in the pathogenesis of DS patients. The calibration curve was linear in a concentration range of 5-40 µg L-1 (R2 > 0.999) with the detection limit of 0.6 µg L-1 level. An acceptable reproducibility (< 3.50%) and good recoveries between 95-98 % were obtained. Reference material was used for method validation.

Keywords: Serum-Selenium level, Downs syndrome, Graphite furnace atomic absorption spectroscopy
Full-Text [PDF 74 kb]   (787 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/03/4
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Amiri M. Serum-Selenium level in patients with Down's syndrome using the graphite furnace atomic absorption spectroscopy . Feyz. 2013; 16 (7) :729-730
URL: http://feyz.kaums.ac.ir/article-1-1831-en.html


Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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