Background: The relation of man with manganese-exposing jobs may cause manganism, a Parkinson-like disease. To find out if the manganese intoxication causes other effects in addition to the brain harms, in this study, histopathological changes and the liver biochemical factors of male Wistar manganic rats were analyzed.

Materials and Methods: The study was on 10 adult male Wistar rats weighing 260-280g classified into the two groups of five, a control group and an experimental group, which received Salin and Manganese chloride respectively. Manganese chloride (8 mg/kg i.p.) was injected to intoxicate for 1 week. Serum for analyzing biochemical factors and the liver central lobe for histopathological evaluations were separated and passaging, formatting, slicing and hemotoxin-eosin coloring were all done on it. The tissue live photographs were taken by CMOS HDCE-10A digital camera and DN2 software and they were analyzed descriptively.

Results: There was a significant increase in the levels of cholesterol and direct bilirubin in the experimental group compared with the control group. OT decreased in the experimental group and there was no significant change in PT, ALP but the coordination of PT on OT had an increase. This increment of enzyme coordination and bilirubin can be a representative for liver harms. Moreover, protein and globulin showed an unexpected increment in the experimental group as well as Albumin. Hepatocyte destruction in the experimental group was observed in histopathologic evaluations.

Conclusion: Manganese intoxication can cause the liver and bilious harms and destruction of liver tissues.