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:: Volume 8, Issue 4 (Quarterly 2005) ::
Feyz 2005, 8(4): 1-5 Back to browse issues page
Comparison of oral versus normal- and high - dose Rectal acetaminophen for reducing fever in childrens
Ahmad Talebian *, Hamid Reza Sherkatolabbasieh, Mohsen Arbabi, Sayed Gholam Abbas Moosavi
, talebian_a@kaums.ac.ir
Abstract:   (5926 Views)

Background: According to high incidence of fever and its side effects in children and also because of different effects of drug regimens on reducing fever, we decided to investigate three kinds of adminstration of acetaminophen (aral with regular dosages, Rectal with regular and high dosages) on children whom were admitted in shaheed Beheshti Hospital in kashan in 2004.

Materials and Methods: This randomized clinical trial was performed among 120 patients aged 6 months to 6 years with fever (axillary temperature ³ 38 ° c). Patients divided in 3 groups. Group A (40 patients) received oral acetaminophen with dose of 10-15 mg/kg acetaminophen. Group B and C received acetaminophen rectally with dose of 10-15 mg/kg and 30-60 mg/kg,respectively. Recovery was defined as reducing axillary temperature at least 1 ° c.Data analysis was performed using Chi Square test.

Results: The frequency of recovery in groups A, B and C after 1 hour of adminstration of acetaminophen was 34 (85%), 32 (80%) and 36 (90%), respectively (p<0.05). It was 37 (92.5%), 38 (95%) and 39 (97/5%) after 3 hours (p<0.001) and 10 (25%), 14 (35%) and 22 (55%) after 6 hours (NS) of administration of acetaminophen in groups A, B and C, respectively

Conclusion: High dose rectal acetaminophen is much more effective in reducing fever of children in comparison of regular dose of acetaminophen, orally or rectally.

Keywords: Oral Acetaminophen, Rectal Acetaminophen, Reducing Fever, children
Full-Text [PDF 191 kb]   (1527 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/11/1
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Talebian A, Sherkatolabbasieh H R, Arbabi M, Moosavi S G A. Comparison of oral versus normal- and high - dose Rectal acetaminophen for reducing fever in childrens. Feyz. 2005; 8 (4) :1-5
URL: http://feyz.kaums.ac.ir/article-1-173-en.html


Volume 8, Issue 4 (Quarterly 2005) Back to browse issues page
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