Background: Genital cancers are the second most common cancer among women (after breast cancer) in some countries. The aim of this study was to determine the trend of the age-standardized incidence rates for female genital cancers in Fars province during 2003-2009.

Materials and Methods: In this descriptive study, using Fars province cancer registry data, the crude incidence rate per 100,000 people and the age-standardized incidence rates were calculated through direct standardization method and using the world standard population. In addition, to evaluate changes in incidence rate trend, the Cochran-Armitage linear trend test was used.

Results: Results showed that ovarian cancer was estimated as the most common cancer of female genital cancers. Age-standardized incidence rate of all female genital cancers during 2003-2009 were 3.7, 3.77, 5.52, 6.62, 9.75 and 12.4 cases per 100,000 people, respectively.

Conclusion: It seems that the incidence rate of female genital cancers in Fars province is the same as the other regions in Iran which exhibits an ascending trend.