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:: Volume 15, Issue 4 (Quarterly 2011) ::
Feyz 2011, 15(4): 345-351 Back to browse issues page
Correlation between serum adiponectin level and blood glucose concentration in adult asthmatic patients
Mojtaba Eizadi, Farzad Nazem *, Laleh Behboodi, Davood Khorshidi
Bu-Ali Sina University , farzadnazem2@gmail.com
Abstract:   (7344 Views)

Background: It has been hypothesized that obesity and disturbance in glucose metabolism can play an important role in the development of asthma. There is accumulating evidence in the literature that obesity can increase both the incidence and severity of asthma. Therefore, this study was conducted to determine the relationship between adiponectin, an anti-inflammatory cytokine, and blood glucose levels in overweight and obese adult patients with asthma.

Materials and Methods: Forty-fine obese or overweight men (age 38-50 years) with mild-to-moderate asthma referred to Saveh health centers participated in this study. Fasting blood glucose, insulin, and adiponectin levels were measured. The homeostasis model assessment (HOMA) was applied to evaluate beta-cell function using fasting glucose and insulin levels. Data were analyzed using Pearson correlation coefficient.

Results: The results of this study showed that there was a significant relationship between the serum adiponectin and FEV1/FVC, FEV1 and FVC in asthma patients. In addition, serum adiponectin level was positively correlated with insulin and beta-cell function, but negatively with fasting glucose level.

Conclusion: According to the results, there is a negative correlation between serum adiponectin levels and blood glucose concentration in adult asthmatic patients. Furthermore, our findings showed that the reduction of systemic adiponectin level influences blood glucose concentration via insulin level and beta-cell function.

Keywords: Beta-cells, Adiponectin, Asthma, Blood glucose
Full-Text [PDF 243 kb]   (1704 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/11/1 | Published: 2011/12/15
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Eizadi M, Nazem F, Behboodi L, Khorshidi D. Correlation between serum adiponectin level and blood glucose concentration in adult asthmatic patients . Feyz. 2011; 15 (4) :345-351
URL: http://feyz.kaums.ac.ir/article-1-1283-en.html

Volume 15, Issue 4 (Quarterly 2011) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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