Background: Accelerating of skin wounds healing process has been focused by researchers in recent years. The aim of the present study was to compare the effects of topical phenytoin, silver sulfadiazine and conjugated estrogen on skin wounds healing in male rats. Accessing a way to accelerate skin wounds healing is still one of the important goals in medical science.

Materials and Methods: This experimental study was accomplished on 32 male rats (8 animals in each group) with approximately equal body mass. Skin wounds were made with an area of 40 mm² and a depth of 0.5 mm on the back of the necks. Three groups were administered daily by topical phenytoin (1%), silver sulfadiazine (1%) and conjugated estrogen (625%). Control group received no drug. Wounds healing was evaluated daily and the study was continued until the wounds healing completed.

Results: Silver sulfadiazine demonstrated to be the best treatment for the wounds healing compared with the other medicines, it required significant shorter time of treatment.

Conclusion: Silver sulfadiazine accelerates skin wounds healing in male rats.